8-bromo-7-(2-(2,6-dimethylphenyl)-2-oxoethyl)-3-methyl-1H-purine-2,6(3H,7H)-dione

Base Information

Chemical Name:8-bromo-7-(2-(2,6-dimethylphenyl)-2-oxoethyl)-3-methyl-1H-purine-2,6(3H,7H)-dione
CAS No.:1415838-47-9
Molecular Formula:C₁₆H₁₅BrN₄O₃
Molecular Weight:391.224
Hs Code.:

Synonyms:8-bromo-7-(2-(2,6-dimethylphenyl)-2-oxoethyl)-3-methyl-1H-purine-2,6(3H,7H)-dione

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Chemical Property of 8-bromo-7-(2-(2,6-dimethylphenyl)-2-oxoethyl)-3-methyl-1H-purine-2,6(3H,7H)-dione

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Technology Process of 8-bromo-7-(2-(2,6-dimethylphenyl)-2-oxoethyl)-3-methyl-1H-purine-2,6(3H,7H)-dione

There total 2 articles about 8-bromo-7-(2-(2,6-dimethylphenyl)-2-oxoethyl)-3-methyl-1H-purine-2,6(3H,7H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 93703-24-3
3-methyl-8-bromoxanthine

: 2633-42-3
2-bromo-2',6'-dimethylacetophenone

: 1415838-47-9
8-bromo-7-(2-(2,6-dimethylphenyl)-2-oxoethyl)-3-methyl-1H-purine-2,6(3H,7H)-dione

Guidance literature:: 3-methyl-8-bromoxanthine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25 ℃; for 0.0833333h; Inert atmosphere; Schlenk technique;

2-bromo-2',6'-dimethylacetophenone; In N,N-dimethyl-formamide; at 110 ℃; for 2h; Inert atmosphere; Schlenk technique;
DOI:10.1021/jm301187e

Reference yield:

: 576-22-7
2-Bromo-m-xylene

: 1415838-47-9
8-bromo-7-(2-(2,6-dimethylphenyl)-2-oxoethyl)-3-methyl-1H-purine-2,6(3H,7H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere; Schlenk technique

1.2: 1 h / -78 °C / Inert atmosphere; Schlenk technique

2.1: pyridinium chlorochromate / dichloromethane / 1 h / 25 °C / Inert atmosphere; Schlenk technique

3.1: copper(I) bromide / chloroform; ethyl acetate / 10 h / Inert atmosphere; Schlenk technique; Reflux

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h / 25 °C / Inert atmosphere; Schlenk technique

4.2: 2 h / 110 °C / Inert atmosphere; Schlenk technique

With n-butyllithium; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; copper(I) bromide; In tetrahydrofuran; hexane; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm301187e