8-(4-fluorophenyl)-9-methyl-9-(1-methyl-1H-imidazol-2-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3 (7H)-one

Base Information

Chemical Name:8-(4-fluorophenyl)-9-methyl-9-(1-methyl-1H-imidazol-2-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3 (7H)-one
CAS No.:1207455-81-9
Molecular Formula:C₂₁H₁₈FN₅O
Molecular Weight:375.405
Hs Code.:

Synonyms:8-(4-fluorophenyl)-9-methyl-9-(1-methyl-1H-imidazol-2-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3 (7H)-one

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Chemical Property of 8-(4-fluorophenyl)-9-methyl-9-(1-methyl-1H-imidazol-2-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3 (7H)-one

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Technology Process of 8-(4-fluorophenyl)-9-methyl-9-(1-methyl-1H-imidazol-2-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3 (7H)-one

There total 6 articles about 8-(4-fluorophenyl)-9-methyl-9-(1-methyl-1H-imidazol-2-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3 (7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1207455-82-0
ethyl 2-(4-fluorophenyl)-3-methyl-3-(1-methyl-1H-imidazol-2-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylaterboxylate

: 1207455-81-9
8-(4-fluorophenyl)-9-methyl-9-(1-methyl-1H-imidazol-2-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3 (7H)-one

Guidance literature:: With hydrazine hydrate; at 67 ℃; for 10h;

Reference yield:

: 641-70-3
3-nitrophthalic acid anhydride

: 1207455-81-9
8-(4-fluorophenyl)-9-methyl-9-(1-methyl-1H-imidazol-2-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3 (7H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 3 h / 0 °C

1.2: pH 1

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 25 °C / 760.05 Torr

3.1: sodium sulfate / dichloromethane / 144 h / 0 - 20 °C

4.1: ethanol / 2 h / 0 - 20 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 0 °C / Inert atmosphere

6.1: hydrazine hydrate / methanol / 10 h / 67 °C

With sodium tetrahydroborate; hydrogen; caesium carbonate; hydrazine hydrate; sodium sulfate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 65399-18-0
4-nitrophthalide

: 1207455-81-9
8-(4-fluorophenyl)-9-methyl-9-(1-methyl-1H-imidazol-2-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3 (7H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 25 °C / 760.05 Torr

2: sodium sulfate / dichloromethane / 144 h / 0 - 20 °C

3: ethanol / 2 h / 0 - 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 4 h / 0 °C / Inert atmosphere

5: hydrazine hydrate / methanol / 10 h / 67 °C

With hydrogen; caesium carbonate; hydrazine hydrate; sodium sulfate; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;