2-(p-tolyl)isonicotinonitrile

Base Information

Chemical Name:2-(p-tolyl)isonicotinonitrile
CAS No.:1039775-36-4
Molecular Formula:C₁₃H₁₀N₂
Molecular Weight:194.236
Hs Code.:

Synonyms:2-(p-tolyl)isonicotinonitrile

Suppliers and Price of 2-(p-tolyl)isonicotinonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2-(p-tolyl)isonicotinonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of 2-(p-tolyl)isonicotinonitrile

There total 3 articles about 2-(p-tolyl)isonicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.9%

: 100-48-1
pyridine-4-carbonitrile

: 5720-05-8
4-methylphenylboronic acid

: 1039775-36-4
2-(p-tolyl)isonicotinonitrile

: 154237-63-5
3-(p-tolyl)isonicotinonitrile

Guidance literature:: With iron sulfide; dipotassium peroxodisulfate; trifluoroacetic acid; In dichloromethane; water; at 20 ℃; for 40h; Overall yield = 85.6%; regioselective reaction;
DOI:10.1039/c2cc35468c

Reference yield:

: 100-48-1
pyridine-4-carbonitrile

: 5720-05-8
4-methylphenylboronic acid

: 253801-11-5
2-(4-formylphenyl)isonicotinonitrile

: 1039775-36-4
2-(p-tolyl)isonicotinonitrile

: 154237-63-5
3-(p-tolyl)isonicotinonitrile

Guidance literature:: With ammonium peroxodisulfate; zinc trifluoromethanesulfonate; silver nitrate; In dichloromethane; water; at 20 ℃; for 4h; Overall yield = 79 %; regioselective reaction;
DOI:10.3987/COM-16-13506

Reference yield:

: 100-48-1
pyridine-4-carbonitrile

: 5720-05-8
4-methylphenylboronic acid

: 1039775-36-4
2-(p-tolyl)isonicotinonitrile

Guidance literature:: pyridine-4-carbonitrile; With Iron(III) nitrate nonahydrate; dipotassium peroxodisulfate; trifluoroacetic acid; In water; at 20 ℃; for 0.166667h; Schlenk technique;

4-methylphenylboronic acid; In water; at 50 ℃; for 24h; Schlenk technique;
DOI:10.1002/ejoc.201300743