{2-[5-(2'-N-tert-butylaminosulfonyl-biphenyl-4-ylcarbamoyl)-3-trifluoromethyl-pyrazol-1-yl]benzyl}-carbamic acid t-butyl ester

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Chemical Name:{2-[5-(2'-N-tert-butylaminosulfonyl-biphenyl-4-ylcarbamoyl)-3-trifluoromethyl-pyrazol-1-yl]benzyl}-carbamic acid t-butyl ester
CAS No.:228259-37-8
Molecular Formula:C₃₃H₃₆F₃N₅O₅S
Molecular Weight:671.741
Hs Code.:

Synonyms:{2-[5-(2'-N-tert-butylaminosulfonyl-biphenyl-4-ylcarbamoyl)-3-trifluoromethyl-pyrazol-1-yl]benzyl}-carbamic acid t-butyl ester

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Chemical Property of {2-[5-(2'-N-tert-butylaminosulfonyl-biphenyl-4-ylcarbamoyl)-3-trifluoromethyl-pyrazol-1-yl]benzyl}-carbamic acid t-butyl ester

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Technology Process of {2-[5-(2'-N-tert-butylaminosulfonyl-biphenyl-4-ylcarbamoyl)-3-trifluoromethyl-pyrazol-1-yl]benzyl}-carbamic acid t-butyl ester

There total 10 articles about {2-[5-(2'-N-tert-butylaminosulfonyl-biphenyl-4-ylcarbamoyl)-3-trifluoromethyl-pyrazol-1-yl]benzyl}-carbamic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 193006-34-7
4-(2'-tert-butylaminosulfonylphenyl)aniline

: [2-(5-chlorocarbonyl-3-trifluoromethyl-pyrazol-1-yl)-benzyl]-carbamic acid tert-butyl ester

: 228259-37-8
{2-[5-(2'-N-tert-butylaminosulfonyl-biphenyl-4-ylcarbamoyl)-3-trifluoromethyl-pyrazol-1-yl]benzyl}-carbamic acid t-butyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 23h;
DOI:10.1021/jm030212h

Reference yield:

: 326-90-9
4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione

: 228259-37-8
{2-[5-(2'-N-tert-butylaminosulfonyl-biphenyl-4-ylcarbamoyl)-3-trifluoromethyl-pyrazol-1-yl]benzyl}-carbamic acid t-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 90 percent / glac. AcOH / 6 h / Heating

2: 100 percent / oxalyl chloride; DMF / CH₂Cl₂ / 4 h

3: 4.76 g / aq. NH₃ / CH₂Cl₂ / 1.5 h / 0 - 20 °C

4: 100 percent / Et₃N; trichloroacetyl chloride / CH₂Cl₂ / 1.42 h / 0 - 20 °C

5: 90 percent / cobalt chloride; sodium borohydride / dimethylformamide / 23.75 h / 0 - 20 °C

6: 76 percent / Et₃N / tetrahydrofuran / 17 h / 20 °C

7: 27 percent / KMnO₄; aq. NaH₂PO₄ / 2-methyl-propan-2-ol / 1.25 h / 60 °C

8: oxalyl chloride; DMF / CH₂Cl₂ / 1.58 h / 20 °C

9: 74 mg / DMAP; Et₃N / CH₂Cl₂ / 23 h / 20 °C

With dmap; ammonium hydroxide; sodium tetrahydroborate; potassium permanganate; sodium dihydrogenphosphate; cobalt chloride; oxalyl dichloride; acetic acid; triethylamine; N,N-dimethyl-formamide; trifluoroacetyl chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jm030212h

Reference yield:

: 5326-27-2
2-hydrazino-benzoic acid

: 228259-37-8
{2-[5-(2'-N-tert-butylaminosulfonyl-biphenyl-4-ylcarbamoyl)-3-trifluoromethyl-pyrazol-1-yl]benzyl}-carbamic acid t-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 90 percent / glac. AcOH / 6 h / Heating

2: 100 percent / oxalyl chloride; DMF / CH₂Cl₂ / 4 h

3: 4.76 g / aq. NH₃ / CH₂Cl₂ / 1.5 h / 0 - 20 °C

4: 100 percent / Et₃N; trichloroacetyl chloride / CH₂Cl₂ / 1.42 h / 0 - 20 °C

5: 90 percent / cobalt chloride; sodium borohydride / dimethylformamide / 23.75 h / 0 - 20 °C

6: 76 percent / Et₃N / tetrahydrofuran / 17 h / 20 °C

7: 27 percent / KMnO₄; aq. NaH₂PO₄ / 2-methyl-propan-2-ol / 1.25 h / 60 °C

8: oxalyl chloride; DMF / CH₂Cl₂ / 1.58 h / 20 °C

9: 74 mg / DMAP; Et₃N / CH₂Cl₂ / 23 h / 20 °C

With dmap; ammonium hydroxide; sodium tetrahydroborate; potassium permanganate; sodium dihydrogenphosphate; cobalt chloride; oxalyl dichloride; acetic acid; triethylamine; N,N-dimethyl-formamide; trifluoroacetyl chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jm030212h