Aids002192

Base Information

• Chemical Name: Aids002192
• CAS No.: 132487-15-1
• Molecular Formula: C10H14N2O4
• Molecular Weight: 226.2292
• Mol file: 132487-15-1.mol

Synonyms:2,3-diOHCH2CyPrT;

Chemical Property of Aids002192

Chemical Property:

• PSA: 95.58000
• Density: 1.397g/cm³
• LogP: -0.97100

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Aids002192

There total 5 articles about Aids002192 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-((2R,3R)-2,3-Bis-benzyloxymethyl-cyclopropyl)-5-methyl-1H-pyrimidine-2,4-dione (132398-82-4,142562-27-4) → 1-(t-2,c-3-dihydroxymethyl-r-1-cyclopropyl)thymine (132398-83-5,132487-15-1)

Guidance literature:

With boron trichloride; In dichloromethane; at -78 ℃;

DOI:10.1248/cpb.38.3184

Reference yield:

C20H21NO3 (132398-74-4,142562-36-5) → 1-(t-2,c-3-dihydroxymethyl-r-1-cyclopropyl)thymine (132398-83-5,132487-15-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 89 percent / NH₃ / toluene / Ambient temperature

2: 80 percent / pyridine / CH₂Cl₂ / 12 h / 0 deg C to RT

3: 65 percent / 25percent NH₄OH / methanol / 85 °C

4: BCl₃ / CH₂Cl₂ / -78 °C

With pyridine; ammonium hydroxide; ammonia; boron trichloride; In methanol; dichloromethane; toluene;

DOI:10.1248/cpb.38.3184

Reference yield:

((2R,3R)-2,3-Bis-benzyloxymethyl-cyclopropyl)-urea (132413-24-2,142562-37-6) → 1-(t-2,c-3-dihydroxymethyl-r-1-cyclopropyl)thymine (132398-83-5,132487-15-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / pyridine / CH₂Cl₂ / 12 h / 0 deg C to RT

2: 65 percent / 25percent NH₄OH / methanol / 85 °C

3: BCl₃ / CH₂Cl₂ / -78 °C

With pyridine; ammonium hydroxide; boron trichloride; In methanol; dichloromethane;

DOI:10.1248/cpb.38.3184

upstream raw materials:

1-((2R,3R)-2,3-Bis-benzyloxymethyl-cyclopropyl)-5-methyl-1H-pyrimidine-2,4-dione

C₂₀H₂₁NO₃

((2R,3R)-2,3-Bis-benzyloxymethyl-cyclopropyl)-urea

1-((2R,3R)-2,3-Bis-benzyloxymethyl-cyclopropyl)-3-((E)-3-methoxy-2-methyl-acryloyl)-urea