(S)-2-(4-(3-aminopiperidin-1-yl)-1,7-naphthyridin-6-yl)-6-(4-fluorophenyl)pyridin-3-amine

Base Information

Chemical Name:(S)-2-(4-(3-aminopiperidin-1-yl)-1,7-naphthyridin-6-yl)-6-(4-fluorophenyl)pyridin-3-amine
CAS No.:1214241-50-5
Molecular Formula:C₂₄H₂₃FN₆
Molecular Weight:414.485
Hs Code.:

Synonyms:(S)-2-(4-(3-aminopiperidin-1-yl)-1,7-naphthyridin-6-yl)-6-(4-fluorophenyl)pyridin-3-amine

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Chemical Property of (S)-2-(4-(3-aminopiperidin-1-yl)-1,7-naphthyridin-6-yl)-6-(4-fluorophenyl)pyridin-3-amine

Chemical Property:

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Technology Process of (S)-2-(4-(3-aminopiperidin-1-yl)-1,7-naphthyridin-6-yl)-6-(4-fluorophenyl)pyridin-3-amine

There total 15 articles about (S)-2-(4-(3-aminopiperidin-1-yl)-1,7-naphthyridin-6-yl)-6-(4-fluorophenyl)pyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₃₁FN₆O₂

: 1214241-50-5
(S)-2-(4-(3-aminopiperidin-1-yl)-1,7-naphthyridin-6-yl)-6-(4-fluorophenyl)pyridin-3-amine

Guidance literature:: With trifluoroacetic acid; In dichloromethane;

Reference yield:

: 1214241-98-1
6-chloro-1,7-naphthyridin-4-ol

: 1214241-50-5
(S)-2-(4-(3-aminopiperidin-1-yl)-1,7-naphthyridin-6-yl)-6-(4-fluorophenyl)pyridin-3-amine

Guidance literature:: Multi-step reaction with 7 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 120 h / 20 °C

3: potassium acetate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.33 h / 135 °C / Microwave irradiation

4: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 0.33 h / 100 °C / Microwave irradiation

5: acetic acid; iron / 14 h

6: water; sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.33 h / 120 °C / Microwave irradiation

7: trifluoroacetic acid / dichloromethane

With water; potassium acetate; iron; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tricyclohexylphosphine; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 1214241-91-4
1-(2-chloro-5-nitropyridin-4-yl)ethanone

: 1214241-50-5
(S)-2-(4-(3-aminopiperidin-1-yl)-1,7-naphthyridin-6-yl)-6-(4-fluorophenyl)pyridin-3-amine

Guidance literature:: Multi-step reaction with 11 steps

1.1: acetic acid; iron / 4 h

2.1: pyridine / 18 h / 20 °C

2.2: Cooling with ice

3.1: lithium hydroxide / water; tetrahydrofuran; methanol / 15 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 96 h / 110 °C

4.2: 15 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 120 h / 20 °C

7.1: potassium acetate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.33 h / 135 °C / Microwave irradiation

8.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 0.33 h / 100 °C / Microwave irradiation

9.1: acetic acid; iron / 14 h

10.1: water; sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.33 h / 120 °C / Microwave irradiation

11.1: trifluoroacetic acid / dichloromethane

With pyridine; water; potassium acetate; iron; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;