2-(6,7-Bis-benzyloxy-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl)-isoindole-1,3-dione

Base Information

Chemical Name:2-(6,7-Bis-benzyloxy-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl)-isoindole-1,3-dione
CAS No.:128217-85-6
Molecular Formula:C₃₁H₂₄N₂O₅
Molecular Weight:504.542
Hs Code.:

Synonyms:2-(6,7-Bis-benzyloxy-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl)-isoindole-1,3-dione

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Chemical Property of 2-(6,7-Bis-benzyloxy-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl)-isoindole-1,3-dione

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Technology Process of 2-(6,7-Bis-benzyloxy-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl)-isoindole-1,3-dione

There total 15 articles about 2-(6,7-Bis-benzyloxy-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl)-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 128217-75-4
3-(4,5-Bis-benzyloxy-2-nitro-phenyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionic acid ethyl ester

: 128217-85-6
2-(6,7-Bis-benzyloxy-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl)-isoindole-1,3-dione

Guidance literature:: With iron; acetic acid; at 90 - 100 ℃; for 3h;
DOI:10.1021/jo00301a008

Reference yield: 52.0%

: 128217-75-4,128299-83-2
3-(4,5-Bis-benzyloxy-2-nitro-phenyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionic acid ethyl ester

: 128217-85-6,128299-86-5
2-(6,7-Bis-benzyloxy-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl)-isoindole-1,3-dione

Guidance literature:: With iron; acetic acid; at 90 - 100 ℃; for 3h;
DOI:10.1021/jo00301a008

Reference yield:

: 22509-74-6
N-ethoxycarbonylphthalimide

: 128217-85-6,128299-86-5
2-(6,7-Bis-benzyloxy-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl)-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 5 steps

1: NaHCO₃ / H₂O; tetrahydrofuran / overnight

2: SOCl₂ / 48 h / Ambient temperature

3: K₂CO₃, NaI / ethanol / 4 h / Heating

4: 75 percent / nitric acid (d = 1.4) / acetic acid / 2 h / 0 °C

5: 52 percent / iron powder, glacial acetic acid / 3 h / 90 - 100 °C

With thionyl chloride; nitric acid; iron; sodium hydrogencarbonate; potassium carbonate; acetic acid; sodium iodide; In tetrahydrofuran; ethanol; water; acetic acid;
DOI:10.1021/jo00301a008