(R_S)-2-methyl-N-((S)-1-(4-trifluoromethylphenyl)ethyl)propane-2-sulfinamide

Base Information

• Chemical Name: (R_S)-2-methyl-N-((S)-1-(4-trifluoromethylphenyl)ethyl)propane-2-sulfinamide
• CAS No.: 911372-69-5
• Molecular Formula: C₁₃H₁₈F₃NOS
• Molecular Weight: 293.353

Synonyms:(R_S)-2-methyl-N-((S)-1-(4-trifluoromethylphenyl)ethyl)propane-2-sulfinamide

Chemical Property of (R_S)-2-methyl-N-((S)-1-(4-trifluoromethylphenyl)ethyl)propane-2-sulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of (R_S)-2-methyl-N-((S)-1-(4-trifluoromethylphenyl)ethyl)propane-2-sulfinamide

There total 2 articles about (R_S)-2-methyl-N-((S)-1-(4-trifluoromethylphenyl)ethyl)propane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(RS)-2-methyl-N-(1-(4-trifluoromethylphenyl)ethylidene)propane-2-sulfinamide (911372-49-1) → (RS)-2-methyl-N-((S)-1-(4-trifluoromethylphenyl)ethyl)propane-2-sulfinamide (911372-69-5) + (RS)-2-methyl-N-((R)-1-(4-trifluoromethylphenyl)ethyl)propane-2-sulfinamide (911372-68-4)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; water; at -50 - 20 ℃; for 3h;

DOI:10.1021/jo0609834

Reference yield:

1-(4-trifluoromethylphenyl)ethanone (709-63-7) → (RS)-2-methyl-N-((S)-1-(4-trifluoromethylphenyl)ethyl)propane-2-sulfinamide (911372-69-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / Ti(OEt)4

2: L-Selectride / tetrahydrofuran / 3 h / 0 - 20 °C

With titanium(IV) tetraethanolate; L-Selectride; In tetrahydrofuran;

DOI:10.1021/jo0609834

Reference yield: 81.0%

(RS)-2-methyl-N-((S)-1-(4-trifluoromethylphenyl)ethyl)propane-2-sulfinamide (911372-69-5) → (S)-α-(p-(trifluoromethyl)phenyl)ethylamine hydrochloride (84499-78-5,856645-99-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

DOI:10.1021/jo0609834

upstream raw materials:

(R_S)-2-methyl-N-(1-(4-trifluoromethylphenyl)ethylidene)propane-2-sulfinamide

1-(4-trifluoromethylphenyl)ethanone

Downstream raw materials:

(S)-α-(p-(trifluoromethyl)phenyl)ethylamine hydrochloride

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