4-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydrofuro[3,2-c]-pyridine hydrochloride

Base Information

Chemical Name:4-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydrofuro[3,2-c]-pyridine hydrochloride
CAS No.:1357260-83-3
Molecular Formula:C₁₄H₁₂F₃NO
Molecular Weight:267.251
Hs Code.:

Synonyms:4-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydrofuro[3,2-c]-pyridine hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydrofuro[3,2-c]-pyridine hydrochloride

Chemical Property:

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Technology Process of 4-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydrofuro[3,2-c]-pyridine hydrochloride

There total 4 articles about 4-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydrofuro[3,2-c]-pyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: tert-butyl 4-(4-(trifluoromethyl)phenyl)-6,7-dihydrofuro[3,2-c]pyridine-5(4H)-carboxylate

: 1357260-83-3
4-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydrofuro[3,2-c]-pyridine hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; diethyl ether; at 20 ℃; for 18h;
DOI:10.1021/jm2013634

Reference yield:

: 1357261-81-4
4-(4-(trifluoromethyl)phenyl)-6,7-dihydrofuro[3,2-c]pyridine

: 1357260-83-3
4-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydrofuro[3,2-c]-pyridine hydrochloride

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1021/jm2013634

Reference yield:

: 329-15-7
4-trifluoromethyl-phenyl acetyl chloride

: 1357260-83-3
4-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydrofuro[3,2-c]-pyridine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 2 h / 20 °C

2: trichlorophosphate / benzene / 2 h / Reflux

3: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 20 °C

With sodium tris(acetoxy)borohydride; triethylamine; trichlorophosphate; In dichloromethane; benzene;
DOI:10.1021/jm2013634