N-{4-[(1S)-1-hydroxyethyl]-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:N-{4-[(1S)-1-hydroxyethyl]-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide
CAS No.:1318757-58-2
Molecular Formula:C₁₈H₁₇F₃N₄O₂S
Molecular Weight:410.42
Hs Code.:

Synonyms:N-{4-[(1S)-1-hydroxyethyl]-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

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Chemical Property of N-{4-[(1S)-1-hydroxyethyl]-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

Chemical Property:

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Technology Process of N-{4-[(1S)-1-hydroxyethyl]-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

There total 9 articles about N-{4-[(1S)-1-hydroxyethyl]-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1318754-61-8
N-{4-(1-hydroxyethyl)-2-[3-(trifluoromethyl}benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

: 1318757-58-2
N-{4-[(1S)-1-hydroxyethyl]-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

: 1318757-57-1
(R)-N-{4-(1-hydroxyethyl)-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: With CHIRALPAK IC; In hexane; isopropyl alcohol; at 30 ℃; Resolution of racemate;

Reference yield:

: 16034-46-1
1-methyl-1H-pyrazole-5-carboxylic acid

: 1318757-58-2
N-{4-[(1S)-1-hydroxyethyl]-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

: 1318757-57-1
(R)-N-{4-(1-hydroxyethyl)-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / ethyl acetate / 5 h / 80 °C

2: N,N-dimethyl acetamide / 3 h / 80 °C

3: diisobutylaluminium hydride / toluene; tetrahydrofuran / 0 - 20 °C

4: Dess-Martin periodane / acetonitrile; tetrahydrofuran / 0 - 20 °C

5: tetrahydrofuran / 1 h / 0 °C

6: CHIRALPAK IC / isopropyl alcohol; hexane / 30 °C / Resolution of racemate

With thionyl chloride; diisobutylaluminium hydride; Dess-Martin periodane; In tetrahydrofuran; hexane; N,N-dimethyl acetamide; ethyl acetate; isopropyl alcohol; toluene; acetonitrile;

Reference yield:

: 2003-14-7
(3-trifluoromethyl-phenyl)-acetyl chloride

: 1318757-58-2
N-{4-[(1S)-1-hydroxyethyl]-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

: 1318757-57-1
(R)-N-{4-(1-hydroxyethyl)-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydrogencarbonate; sodium dithionite / water / 2 h / 20 °C

1.2: 0 - 20 °C

2.1: Lawessons reagent / toluene / 6 h / 80 °C

3.1: N,N-dimethyl acetamide / 3 h / 80 °C

4.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 0 - 20 °C

5.1: Dess-Martin periodane / acetonitrile; tetrahydrofuran / 0 - 20 °C

6.1: tetrahydrofuran / 1 h / 0 °C

7.1: CHIRALPAK IC / isopropyl alcohol; hexane / 30 °C / Resolution of racemate

With Lawessons reagent; sodium dithionite; diisobutylaluminium hydride; sodium hydrogencarbonate; Dess-Martin periodane; In tetrahydrofuran; hexane; N,N-dimethyl acetamide; water; isopropyl alcohol; toluene; acetonitrile;