trans-4-[2-[(4R)-benzyloxy-1-(tert-butoxycarbonyl)-(2S)-pyrrolidinyl]-1-ethenyl]benzoic acid methyl ester

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Chemical Name:trans-4-[2-[(4R)-benzyloxy-1-(tert-butoxycarbonyl)-(2S)-pyrrolidinyl]-1-ethenyl]benzoic acid methyl ester
CAS No.:942310-03-4
Molecular Formula:C₂₆H₃₁NO₅
Molecular Weight:437.536
Hs Code.:

Synonyms:trans-4-[2-[(4R)-benzyloxy-1-(tert-butoxycarbonyl)-(2S)-pyrrolidinyl]-1-ethenyl]benzoic acid methyl ester

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Chemical Property of trans-4-[2-[(4R)-benzyloxy-1-(tert-butoxycarbonyl)-(2S)-pyrrolidinyl]-1-ethenyl]benzoic acid methyl ester

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Technology Process of trans-4-[2-[(4R)-benzyloxy-1-(tert-butoxycarbonyl)-(2S)-pyrrolidinyl]-1-ethenyl]benzoic acid methyl ester

There total 2 articles about trans-4-[2-[(4R)-benzyloxy-1-(tert-butoxycarbonyl)-(2S)-pyrrolidinyl]-1-ethenyl]benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 166977-94-2
methyl 4-((diethoxyphosphoryloxy)methyl)benzoate

: 136024-61-8
(4R)-benzyloxy-(2S)-formylpyrrolidine-1-carboxylic acid tert-butyl ester

: 942310-03-4
trans-4-[2-[(4R)-benzyloxy-1-(tert-butoxycarbonyl)-(2S)-pyrrolidinyl]-1-ethenyl]benzoic acid methyl ester

Guidance literature:: methyl 4-((diethoxyphosphoryloxy)methyl)benzoate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

(4R)-benzyloxy-(2S)-formylpyrrolidine-1-carboxylic acid tert-butyl ester; In tetrahydrofuran; at -78 - 0 ℃; for 2h;

Reference yield:

: 109953-95-9
tert-butyl (2S,4R)-4-(benzyloxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

: 942310-03-4
trans-4-[2-[(4R)-benzyloxy-1-(tert-butoxycarbonyl)-(2S)-pyrrolidinyl]-1-ethenyl]benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid / dichloromethane / 2 h / 0 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

2.2: 2 h / -78 - 0 °C

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

Reference yield:

: 942310-03-4
trans-4-[2-[(4R)-benzyloxy-1-(tert-butoxycarbonyl)-(2S)-pyrrolidinyl]-1-ethenyl]benzoic acid methyl ester

: cis-4-[2-[1-(tert-butoxycarbonyl)-(4R)-hydroxy-(2S)-pyrrolidinyl]ethyl]cyclohexanecarboxylic acid methyl ester

: trans-4-[2-[1-(tert-butoxycarbonyl)-(4R)-hydroxy-(2S)-pyrrolidinyl]ethyl]cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium dihydroxide / methanol / 12 h / 20 °C

2: hydrogen / Rh/Al₂O₃ / methanol; acetic acid / 3 h / 20 °C / 11400.8 Torr

With hydrogen; palladium dihydroxide; Rh/Al₂O₃; In methanol; acetic acid;