7,8-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid [2-(4-fluorophenyl)ethyl]amide

Base Information

Chemical Name:7,8-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid [2-(4-fluorophenyl)ethyl]amide
CAS No.:283178-80-3
Molecular Formula:C₂₀H₁₉FN₂O₄
Molecular Weight:370.38
Hs Code.:

Synonyms:7,8-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid [2-(4-fluorophenyl)ethyl]amide

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Chemical Property of 7,8-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid [2-(4-fluorophenyl)ethyl]amide

Chemical Property:

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Technology Process of 7,8-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid [2-(4-fluorophenyl)ethyl]amide

There total 7 articles about 7,8-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid [2-(4-fluorophenyl)ethyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1338350-69-8
C₁₂H₁₀ClNO₄

: 1583-88-6
4-fluoro-2-phenethylamine

: 283178-80-3
7,8-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid [2-(4-fluorophenyl)ethyl]amide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 0.5h;
DOI:10.1016/j.bmc.2011.07.062

Reference yield:

: 55149-84-3
2-nitroveratraldehyde

: 283178-80-3
7,8-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid [2-(4-fluorophenyl)ethyl]amide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride; iron; acetic acid / water; ethyl acetate / 0.25 h / Reflux

2: piperidine; acetic acid / ethanol / 16 h / Reflux; Inert atmosphere

3: hydrogenchloride; water / ethanol / 60 °C

4: thionyl chloride / toluene / 3 h / Reflux; Inert atmosphere

5: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

With piperidine; hydrogenchloride; thionyl chloride; water; iron; acetic acid; triethylamine; In ethanol; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1016/j.bmc.2011.07.062

Reference yield:

: 800412-52-6
C₁₄H₁₅NO₅

: 283178-80-3
7,8-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid [2-(4-fluorophenyl)ethyl]amide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; water / ethanol / 60 °C

2: thionyl chloride / toluene / 3 h / Reflux; Inert atmosphere

3: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

With hydrogenchloride; thionyl chloride; water; triethylamine; In ethanol; dichloromethane; toluene;
DOI:10.1016/j.bmc.2011.07.062