(R)-tert-butyl 1-(4-bromo-1-tosyl-1H-indol-3-yl)but-3-yn-2-yl(methyl)carbamate

Base Information

Chemical Name:(R)-tert-butyl 1-(4-bromo-1-tosyl-1H-indol-3-yl)but-3-yn-2-yl(methyl)carbamate
CAS No.:1228274-07-4
Molecular Formula:C₂₅H₂₇BrN₂O₄S
Molecular Weight:531.47
Hs Code.:

Synonyms:(R)-tert-butyl 1-(4-bromo-1-tosyl-1H-indol-3-yl)but-3-yn-2-yl(methyl)carbamate

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Chemical Property of (R)-tert-butyl 1-(4-bromo-1-tosyl-1H-indol-3-yl)but-3-yn-2-yl(methyl)carbamate

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Technology Process of (R)-tert-butyl 1-(4-bromo-1-tosyl-1H-indol-3-yl)but-3-yn-2-yl(methyl)carbamate

There total 1 articles about (R)-tert-butyl 1-(4-bromo-1-tosyl-1H-indol-3-yl)but-3-yn-2-yl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1228274-06-3
tert-butyl (R)-1-(4-bromo-1-tosyl-1H-indol-3-yl)but-3-yn-2-ylcarbamate

: 77-78-1
dimethyl sulfate

: 1228274-07-4
(R)-tert-butyl 1-(4-bromo-1-tosyl-1H-indol-3-yl)but-3-yn-2-yl(methyl)carbamate

Guidance literature:: tert-butyl (R)-1-(4-bromo-1-tosyl-1H-indol-3-yl)but-3-yn-2-ylcarbamate; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;

dimethyl sulfate; In tetrahydrofuran; at -78 ℃;
DOI:10.1021/ol100819f

Reference yield:

: 1228274-07-4
(R)-tert-butyl 1-(4-bromo-1-tosyl-1H-indol-3-yl)but-3-yn-2-yl(methyl)carbamate

: 1228274-05-2
(R)-N-methyl-6-methylene-2-tosyl-2,6,7,8-tetrahydrobenzo[cd]indol-7-amine

Guidance literature:: (R)-tert-butyl 1-(4-bromo-1-tosyl-1H-indol-3-yl)but-3-yn-2-yl(methyl)carbamate; With 1,2,2,6,6-pentamethylpiperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; formic acid; tetrabutyl-ammonium chloride; In acetonitrile; at 80 ℃; for 2h;

With toluene-4-sulfonic acid; In methanol; water; at 35 ℃;
DOI:10.1021/ol100819f

Reference yield:

: 1228274-07-4
(R)-tert-butyl 1-(4-bromo-1-tosyl-1H-indol-3-yl)but-3-yn-2-yl(methyl)carbamate

: C₂₅H₂₈N₂O₄S

: C₂₅H₂₈N₂O₄S

Guidance literature:: With 1,2,2,6,6-pentamethylpiperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; formic acid; tetrabutyl-ammonium chloride; In acetonitrile; at 80 ℃; for 2h;
DOI:10.1021/ol100819f