1,2-dihydro-6-(3-cyano-5-fluorophenyl)-2,2,4-trimethyl-1-t-butoxycarbonylquinoline

Base Information

Chemical Name:1,2-dihydro-6-(3-cyano-5-fluorophenyl)-2,2,4-trimethyl-1-t-butoxycarbonylquinoline
CAS No.:199611-77-3
Molecular Formula:C₂₄H₂₅FN₂O₂
Molecular Weight:392.473
Hs Code.:

Synonyms:1,2-dihydro-6-(3-cyano-5-fluorophenyl)-2,2,4-trimethyl-1-t-butoxycarbonylquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,2-dihydro-6-(3-cyano-5-fluorophenyl)-2,2,4-trimethyl-1-t-butoxycarbonylquinoline

Chemical Property:

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Technology Process of 1,2-dihydro-6-(3-cyano-5-fluorophenyl)-2,2,4-trimethyl-1-t-butoxycarbonylquinoline

There total 2 articles about 1,2-dihydro-6-(3-cyano-5-fluorophenyl)-2,2,4-trimethyl-1-t-butoxycarbonylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1435-51-4
1,3-dibromo-5-fluorobenzene

: 199611-77-3
1,2-dihydro-6-(3-cyano-5-fluorophenyl)-2,2,4-trimethyl-1-t-butoxycarbonylquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dimethylformamide / 3 h / Heating

2: (Ph₃P)4Pd, K₂CO₃ / toluene; ethanol / 4 h / Heating

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm9801915

Reference yield:

: 179898-34-1
3-bromo-5-fluorobenzonitrile

: 179894-36-1
(1-tert-butyloxycarbonyl-1,2-dihydro-2,2,4-trimethyl-6-quinolinyl)boronic acid

: 199611-77-3
1,2-dihydro-6-(3-cyano-5-fluorophenyl)-2,2,4-trimethyl-1-t-butoxycarbonylquinoline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; for 4h; Heating;
DOI:10.1021/jm9801915