5,7-Dimethoxy-3-(4-pyridinyl)quinoline

Base Information

Chemical Name:5,7-Dimethoxy-3-(4-pyridinyl)quinoline
CAS No.:137206-97-4
Molecular Formula:C₁₆H₁₄N₂O₂
Molecular Weight:266.299
Hs Code.:2933990090
DSSTox Substance ID:DTXSID90160107
Nikkaji Number:J433.456F
Wikidata:Q83028484
Pharos Ligand ID:BCWSZP1PK6N8
ChEMBL ID:CHEMBL68423
Mol file:137206-97-4.mol

Synonyms:5,7-dimethoxy-3-(4-pyridinyl)quinoline;5,7-DMPQ

Suppliers and Price of 5,7-Dimethoxy-3-(4-pyridinyl)quinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
DMPQ dihydrochloride
10mg
$ 403.00

Tocris
DMPQ dihydrochloride ≥99%(HPLC)
50
$ 567.00

Tocris
DMPQ dihydrochloride ≥99%(HPLC)
10
$ 149.00

Sigma-Aldrich
DMPQ dihydrochloride ≥98% (HPLC)
25 mg
$ 384.00

Sigma-Aldrich
DMPQ dihydrochloride ≥98% (HPLC)
5 mg
$ 97.60

American Custom Chemicals Corporation
DMPQ DIHYDROCHLORIDE 95.00%
10MG
$ 665.81

American Custom Chemicals Corporation
DMPQ DIHYDROCHLORIDE 95.00%
1MG
$ 135.45

Total 8 raw suppliers

Chemical Property of 5,7-Dimethoxy-3-(4-pyridinyl)quinoline

Chemical Property:

Vapor Pressure:1.43E-07mmHg at 25°C
Boiling Point:441.3°C at 760 mmHg
Flash Point:158.7°C
PSA：44.24000
Density:1.192g/cm³
LogP:4.91800
Storage Temp.:Store at RT
Solubility.:Soluble in DMSO (up to 1 mg/ml with warming) or in Water (up to 30 mg/ml).
XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:266.105527694
Heavy Atom Count:20
Complexity:307

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

DMPQ dihydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC2=C(C=C(C=N2)C3=CC=NC=C3)C(=C1)OC
Description DMPQ 2HCl (137206-97-4) is a potent and selective inhibitor of PDGFRβ, IC50=80 nM. Greater than 100-fold more selective compared to EGFR, erB2, p56, PKA and PKC. Cell permeable.
Uses DMPQ dihydrochloride is a selective an a potent inhibitor of human platelet-derived growth factor receptor β (PDGFRβ).

Technology Process of 5,7-Dimethoxy-3-(4-pyridinyl)quinoline

There total 3 articles about 5,7-Dimethoxy-3-(4-pyridinyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 137207-05-7
(E)-3-(3,5-Dimethoxy-phenylamino)-2-pyridin-4-yl-propenal

: 137206-97-4
CN-9

Guidance literature:: With acetic acid; for 7h; heating by steam bath;

Reference yield:

: 26866-49-9
α-[(dimethylamino)-methylene]-4-pyridineacetaldehyde

: 137206-97-4
CN-9

Guidance literature:: Multi-step reaction with 2 steps

1: 3 h / 120 - 130 °C

2: 55 percent / acetic acid / 7 h / heating by steam bath

With acetic acid;

Reference yield:

: 10272-07-8
3.5-dimethoxyaniline

: 137206-97-4
CN-9

Guidance literature:: Multi-step reaction with 2 steps

1: 3 h / 120 - 130 °C

2: 55 percent / acetic acid / 7 h / heating by steam bath

With acetic acid;