3-(trans-2-hydroxycyclohexylmethyl)but-2-enolide

Base Information

Chemical Name:3-(trans-2-hydroxycyclohexylmethyl)but-2-enolide
CAS No.:130826-71-0
Molecular Formula:C₁₁H₁₆O₃
Molecular Weight:196.246
Hs Code.:

Synonyms:3-(trans-2-hydroxycyclohexylmethyl)but-2-enolide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(trans-2-hydroxycyclohexylmethyl)but-2-enolide

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Technology Process of 3-(trans-2-hydroxycyclohexylmethyl)but-2-enolide

There total 11 articles about 3-(trans-2-hydroxycyclohexylmethyl)but-2-enolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 130826-72-1
3-(trans-2-acetoxycyclohexylmethyl)but-2-enolide

: 130826-71-0
3-(trans-2-hydroxycyclohexylmethyl)but-2-enolide

Guidance literature:: With hydrogenchloride; In diethyl ether; ethanol; for 72h; Ambient temperature;
DOI:10.1016/0223-5234(90)90004-M

Reference yield: 17.7%

: 130826-74-3
ethyl 4-acetoxy-3-(trans-2-acetoxycyclohexylmethyl)-(Z)-2-butenoate

: 130826-71-0
3-(trans-2-hydroxycyclohexylmethyl)but-2-enolide

: 130826-72-1
3-(trans-2-acetoxycyclohexylmethyl)but-2-enolide

Guidance literature:: With hydrogenchloride; In diethyl ether; ethanol; for 72h; Ambient temperature;
DOI:10.1016/0223-5234(90)90004-M

Reference yield:

: 5426-58-4,69198-05-6,75364-90-8,112138-17-7
trans-(2-hydroxy-cyclohexyl)acetic acid

: 130826-71-0
3-(trans-2-hydroxycyclohexylmethyl)but-2-enolide

Guidance literature:: Multi-step reaction with 9 steps

1: 42.5 percent / potassium fluoride / dimethylformamide / 48 h / Ambient temperature

2: 86 percent / Et₃N / benzene

3: 83.9 percent / acetic acid, Zn / 4 h / Ambient temperature

4: thionylchloride / benzene

5: diethyl ether / 3 h / -5 - 0 °C

6: HCl / diethyl ether / 0.5 h

7: 70 percent / sodium acetate / 4 h / Heating

8: 1.) NaH / 1.) benzene, RT, 2.) a) RT, 30 min, b) 40 deg C, 20 min, c) 25 deg C, 21 h

9: 82 percent / HCl / diethyl ether; ethanol / 72 h / Ambient temperature

With hydrogenchloride; potassium fluoride; thionyl chloride; sodium acetate; sodium hydride; acetic acid; triethylamine; zinc; In diethyl ether; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1016/0223-5234(90)90004-M