2-(2-cyclobutyloxy-5-hydroxymethyl-3-methyl-benzoylamino)-indan-2-carboxylic acid

Base Information

Chemical Name:2-(2-cyclobutyloxy-5-hydroxymethyl-3-methyl-benzoylamino)-indan-2-carboxylic acid
CAS No.:1092446-86-0
Molecular Formula:C₂₃H₂₅NO₅
Molecular Weight:395.455
Hs Code.:

Synonyms:2-(2-cyclobutyloxy-5-hydroxymethyl-3-methyl-benzoylamino)-indan-2-carboxylic acid

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Chemical Property of 2-(2-cyclobutyloxy-5-hydroxymethyl-3-methyl-benzoylamino)-indan-2-carboxylic acid

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Technology Process of 2-(2-cyclobutyloxy-5-hydroxymethyl-3-methyl-benzoylamino)-indan-2-carboxylic acid

There total 5 articles about 2-(2-cyclobutyloxy-5-hydroxymethyl-3-methyl-benzoylamino)-indan-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1092448-59-3
2-(2-cyclobutyloxy-5-hydroxymethyl-3-methyl-benzoylamino)-indan-2-carboxylic acid ethyl ester

: 1092446-86-0
2-(2-cyclobutyloxy-5-hydroxymethyl-3-methyl-benzoylamino)-indan-2-carboxylic acid

Guidance literature:: 2-(2-cyclobutyloxy-5-hydroxymethyl-3-methyl-benzoylamino)-indan-2-carboxylic acid ethyl ester; With potassium hydroxide; ethanol; water; at 20 ℃; for 0.5h;

With hydrogenchloride; water;

Reference yield:

: 23287-26-5
3-methylsalicylic acid methyl ester

: 1092446-86-0
2-(2-cyclobutyloxy-5-hydroxymethyl-3-methyl-benzoylamino)-indan-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: trifluoroacetic acid / 78 °C

1.2: 2 h / 50 °C

2.1: caesium carbonate; potassium iodide / N,N-dimethyl-formamide / 6 h / 110 °C

3.1: sodium tetrahydroborate / hexane / 40 °C

4.1: potassium hydroxide; ethanol; water / 1 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

6.1: potassium hydroxide; ethanol; water / 0.5 h / 20 °C

With potassium hydroxide; sodium tetrahydroborate; ethanol; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; potassium iodide; In hexane; N,N-dimethyl-formamide;

Reference yield:

: 91-13-4
α,α'-dibromo-o-xylene

: 1092446-86-0
2-(2-cyclobutyloxy-5-hydroxymethyl-3-methyl-benzoylamino)-indan-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / acetonitrile / 75 °C

2.1: hydrogenchloride; water / ethanol / 5 h / 20 °C

2.2: pH 10

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

4.1: potassium hydroxide; ethanol; water / 0.5 h / 20 °C

With hydrogenchloride; potassium hydroxide; ethanol; water; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; N,N-dimethyl-formamide; acetonitrile;