3-(benzyloxy)-5-[3-[2-[tert-butyl(dimethyl)silanyloxy]ethyl]-5-isoxazolyl]pyridine

Base Information

Chemical Name:3-(benzyloxy)-5-[3-[2-[tert-butyl(dimethyl)silanyloxy]ethyl]-5-isoxazolyl]pyridine
CAS No.:1404372-73-1
Molecular Formula:C₂₃H₃₀N₂O₃Si
Molecular Weight:410.588
Hs Code.:

Synonyms:3-(benzyloxy)-5-[3-[2-[tert-butyl(dimethyl)silanyloxy]ethyl]-5-isoxazolyl]pyridine

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Chemical Property of 3-(benzyloxy)-5-[3-[2-[tert-butyl(dimethyl)silanyloxy]ethyl]-5-isoxazolyl]pyridine

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Technology Process of 3-(benzyloxy)-5-[3-[2-[tert-butyl(dimethyl)silanyloxy]ethyl]-5-isoxazolyl]pyridine

There total 6 articles about 3-(benzyloxy)-5-[3-[2-[tert-butyl(dimethyl)silanyloxy]ethyl]-5-isoxazolyl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1404372-70-8
3-(benzyloxy)-5-ethynylpyridine

: 107833-78-3
1-(tert-butyldimethylsilyloxy)-3-nitropropane

: 1404372-73-1
3-(benzyloxy)-5-[3-[2-[tert-butyl(dimethyl)silanyloxy]ethyl]-5-isoxazolyl]pyridine

Guidance literature:: With phenyl isocyanate; triethylamine; In toluene; at 60 ℃; Inert atmosphere;
DOI:10.1021/jm301177j

Reference yield:

: 130722-95-1
3-(benzyloxy)-5-bromopyridine

: 1404372-73-1
3-(benzyloxy)-5-[3-[2-[tert-butyl(dimethyl)silanyloxy]ethyl]-5-isoxazolyl]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 0.5 h / 20 °C / Inert atmosphere

1.2: Sonogashira Cross-Coupling / 24 h / 60 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere; Cooling with ice

3.1: phenyl isocyanate; triethylamine / toluene / 60 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; phenyl isocyanate; triethylamine; triphenylphosphine; In tetrahydrofuran; toluene; 1.1: |Sonogashira Cross-Coupling;
DOI:10.1021/jm301177j

Reference yield:

: 1421863-09-3
C₁₇H₁₉NOSi

: 1404372-73-1
3-(benzyloxy)-5-[3-[2-[tert-butyl(dimethyl)silanyloxy]ethyl]-5-isoxazolyl]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere; Cooling with ice

2: phenyl isocyanate; triethylamine / toluene / 60 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; phenyl isocyanate; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1021/jm301177j