N-[4-(3-oxo-7-{2-oxo-2-[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]ethyl}-3,7-dihydroimidazo[1,2-a]pyrazin-2-yl)phenyl]-1-(phenylacetyl)-L-prolinamide

Base Information

Chemical Name:N-[4-(3-oxo-7-{2-oxo-2-[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]ethyl}-3,7-dihydroimidazo[1,2-a]pyrazin-2-yl)phenyl]-1-(phenylacetyl)-L-prolinamide
CAS No.:1246468-39-2
Molecular Formula:C₃₉H₃₈N₆O₅
Molecular Weight:670.768
Hs Code.:

Synonyms:N-[4-(3-oxo-7-{2-oxo-2-[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]ethyl}-3,7-dihydroimidazo[1,2-a]pyrazin-2-yl)phenyl]-1-(phenylacetyl)-L-prolinamide

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Chemical Property of N-[4-(3-oxo-7-{2-oxo-2-[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]ethyl}-3,7-dihydroimidazo[1,2-a]pyrazin-2-yl)phenyl]-1-(phenylacetyl)-L-prolinamide

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Technology Process of N-[4-(3-oxo-7-{2-oxo-2-[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]ethyl}-3,7-dihydroimidazo[1,2-a]pyrazin-2-yl)phenyl]-1-(phenylacetyl)-L-prolinamide

There total 9 articles about N-[4-(3-oxo-7-{2-oxo-2-[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]ethyl}-3,7-dihydroimidazo[1,2-a]pyrazin-2-yl)phenyl]-1-(phenylacetyl)-L-prolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246470-89-2
C₂₆H₂₅N₅O₃

: 2752-38-7
(S)-1-(2-phenylacetyl)pyrrolidine-2-carboxylic acid

: 1246468-39-2
N-[4-(3-oxo-7-{2-oxo-2-[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]ethyl}-3,7-dihydroimidazo[1,2-a]pyrazin-2-yl)phenyl]-1-(phenylacetyl)-L-prolinamide

Guidance literature:: C₂₆H₂₅N₅O₃; (S)-1-(2-phenylacetyl)pyrrolidine-2-carboxylic acid; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 0.0833333h;

With HATU; In acetonitrile; at 20 ℃;

Reference yield:

: 100-19-6
(4-nitrophenyl)ethanone

: 1246468-39-2
N-[4-(3-oxo-7-{2-oxo-2-[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]ethyl}-3,7-dihydroimidazo[1,2-a]pyrazin-2-yl)phenyl]-1-(phenylacetyl)-L-prolinamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen bromide; dimethyl sulfoxide / water / 55 °C

2: boron trifluoride diethyl etherate / dichloromethane

3: triethylamine / tetrahydrofuran / 25 °C

4: tin(II) chloride dihdyrate / ethanol / 2 h / 70 °C

5: HATU; N-ethyl-N,N-diisopropylamine / acetonitrile / 25 °C

With tin(II) chloride dihdyrate; boron trifluoride diethyl etherate; hydrogen bromide; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 1246470-85-8
C₁₂H₈N₄O₃

: 1246468-39-2
N-[4-(3-oxo-7-{2-oxo-2-[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]ethyl}-3,7-dihydroimidazo[1,2-a]pyrazin-2-yl)phenyl]-1-(phenylacetyl)-L-prolinamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 25 °C

2: tin(II) chloride dihdyrate / ethanol / 2 h / 70 °C

3: HATU; N-ethyl-N,N-diisopropylamine / acetonitrile / 25 °C

With tin(II) chloride dihdyrate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; ethanol; acetonitrile;