Technology Process of 3-[4-(N-hydroxycarbamimidoyl)-2,6-dimethyl-phenyl]-propionic acid tert-butyl ester
There total 8 articles about 3-[4-(N-hydroxycarbamimidoyl)-2,6-dimethyl-phenyl]-propionic acid tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydroxylamine hydrochloride; triethylamine;
In
methanol;
for 2h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 16 h / 20 °C / 1875.19 Torr
2.1: lithium hydroxide; water / ethanol / 4.5 h / 0 - 20 °C
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / isopropyl alcohol / 1 h / 20 °C
3.2: 0.5 h
4.1: triethylamine / dichloromethane / 1 h / 15 - 20 °C
5.1: hydroxylamine hydrochloride; triethylamine / methanol / 2 h / Heating / reflux
With
lithium hydroxide; hydroxylamine hydrochloride; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine / palladium diacetate; 1,3-bis-(diphenylphosphino)propane / N,N-dimethyl-formamide / 22 h / 115 °C
2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 16 h / 20 °C / 1875.19 Torr
3.1: lithium hydroxide; water / ethanol / 4.5 h / 0 - 20 °C
4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / isopropyl alcohol / 1 h / 20 °C
4.2: 0.5 h
5.1: triethylamine / dichloromethane / 1 h / 15 - 20 °C
6.1: hydroxylamine hydrochloride; triethylamine / methanol / 2 h / Heating / reflux
With
lithium hydroxide; hydroxylamine hydrochloride; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
palladium diacetate; palladium 10% on activated carbon; 1,3-bis-(diphenylphosphino)propane;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
