1-{(1S,2R,3R,6S)-7-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2,6-dimethyl-heptyloxymethyl}-4-methoxy-benzene

Base Information

Chemical Name:1-{(1S,2R,3R,6S)-7-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2,6-dimethyl-heptyloxymethyl}-4-methoxy-benzene
CAS No.:934165-96-5
Molecular Formula:C₃₉H₆₈O₅Si₂
Molecular Weight:673.137
Hs Code.:

1-{(1S,2R,3R,6S)-7-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2,6-dimethyl-heptyloxymethyl}-4-methoxy-benzene

Synonyms:1-{(1S,2R,3R,6S)-7-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2,6-dimethyl-heptyloxymethyl}-4-methoxy-benzene

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Chemical Property of 1-{(1S,2R,3R,6S)-7-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2,6-dimethyl-heptyloxymethyl}-4-methoxy-benzene

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Technology Process of 1-{(1S,2R,3R,6S)-7-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2,6-dimethyl-heptyloxymethyl}-4-methoxy-benzene

There total 6 articles about 1-{(1S,2R,3R,6S)-7-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2,6-dimethyl-heptyloxymethyl}-4-methoxy-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 934165-95-4
(2S,3S,4S,5R,8S)-9-benzyloxy-3-(4-methoxy-benzyloxy)-2,4,8-trimethyl-nonane-1,5-diol

: 69739-34-0
t-butyldimethylsiyl triflate

: 934165-96-5
1-{(1S,2R,3R,6S)-7-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2,6-dimethyl-heptyloxymethyl}-4-methoxy-benzene

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at -78 ℃; for 0.5h;
DOI:10.1016/j.tet.2007.01.067

Reference yield:

: 934165-89-6
((S)-2-methyl-but-3-ynyloxymethyl)-benzene

: 934165-96-5
1-{(1S,2R,3R,6S)-7-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2,6-dimethyl-heptyloxymethyl}-4-methoxy-benzene

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / zinc triflate; (-)-(1R,2S)-N-methyl-ephedrine; triethylamine / toluene / 24 h / 20 °C

2: 82 percent / hydrogen / Rh(PPh₃)3Cl / benzene

3: 82 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / -78 °C

With 2,6-dimethylpyridine; hydrogen; zinc trifluoromethanesulfonate; triethylamine; Wilkinson's catalyst; In dichloromethane; toluene; benzene; 1: Carreira asymmetric alkynylation;
DOI:10.1016/j.tet.2007.01.067

Reference yield:

: 79026-61-2
(R)-3-benzyloxy-2-methylpropanal

: 934165-96-5
1-{(1S,2R,3R,6S)-7-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2,6-dimethyl-heptyloxymethyl}-4-methoxy-benzene

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methoxide / tetrahydrofuran; methanol / -78 °C

1.2: 78 percent / tetrahydrofuran; methanol / 0.5 h / -78 °C

2.1: 96 percent / zinc triflate; (-)-(1R,2S)-N-methyl-ephedrine; triethylamine / toluene / 24 h / 20 °C

3.1: 82 percent / hydrogen / Rh(PPh₃)3Cl / benzene

4.1: 82 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / -78 °C

With 2,6-dimethylpyridine; hydrogen; sodium methylate; zinc trifluoromethanesulfonate; triethylamine; Wilkinson's catalyst; In tetrahydrofuran; methanol; dichloromethane; toluene; benzene; 2.1: Carreira asymmetric alkynylation;
DOI:10.1016/j.tet.2007.01.067