3-<2-(3-indolyl)ethyl>-4-oxo-8-(phenylthio)-cis-3-azabicyclo<4.4.0>dec-7-ene

Base Information

Chemical Name:3-<2-(3-indolyl)ethyl>-4-oxo-8-(phenylthio)-cis-3-azabicyclo<4.4.0>dec-7-ene
CAS No.:99766-15-1
Molecular Formula:C₂₅H₂₆N₂OS
Molecular Weight:402.56
Hs Code.:

Synonyms:3-<2-(3-indolyl)ethyl>-4-oxo-8-(phenylthio)-cis-3-azabicyclo<4.4.0>dec-7-ene

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Chemical Property of 3-<2-(3-indolyl)ethyl>-4-oxo-8-(phenylthio)-cis-3-azabicyclo<4.4.0>dec-7-ene

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Technology Process of 3-<2-(3-indolyl)ethyl>-4-oxo-8-(phenylthio)-cis-3-azabicyclo<4.4.0>dec-7-ene

There total 5 articles about 3-<2-(3-indolyl)ethyl>-4-oxo-8-(phenylthio)-cis-3-azabicyclo<4.4.0>dec-7-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.9%

: 99766-10-6
3-<2-(3-indolyl)ethyl>-4-oxo-5-(p-tolylsulfonyl)-8-(phenylthio)-cis-3-azabicyclo<4.4.0>dec-7-ene

: 99766-15-1
3-<2-(3-indolyl)ethyl>-4-oxo-8-(phenylthio)-cis-3-azabicyclo<4.4.0>dec-7-ene

Guidance literature:: With disodium hydrogenphosphate; sodium amalgam; In methanol; for 1h; Ambient temperature;
DOI:10.1021/jo00354a015

Reference yield:

: 61-54-1
tryptamine

: 99766-15-1
3-<2-(3-indolyl)ethyl>-4-oxo-8-(phenylthio)-cis-3-azabicyclo<4.4.0>dec-7-ene

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) MgSO₄, 2.) NaBH₄ / 1.) methylene dichloride, -23 dec C, 11 h, 2.) methylene dichloride, methanol, -63 deg C, 0.75 h

2: 94 percent / Et₃N / CH₂Cl₂ / 0.25 h / -23 °C

3: 94 percent / NaH, Pd(diphos)2 / 1,2-dimethoxy-ethane / 1.) 0 deg C, 40 min, 2.) 85 deg C, 10 min

4: 90.9 percent / Na₂HPO₄, (Na)Hg / methanol / 1 h / Ambient temperature

With sodium tetrahydroborate; disodium hydrogenphosphate; sodium amalgam; bis[1,2-bis(diphenylphosphino)ethane]palladium⁽⁰⁾; sodium hydride; magnesium sulfate; triethylamine; In methanol; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/jo00354a015

Reference yield:

: 90083-86-6,99766-07-1
cis-3-Acetoxy-4-formyl-1-(phenylthio)cyclohexene

: 99766-15-1
3-<2-(3-indolyl)ethyl>-4-oxo-8-(phenylthio)-cis-3-azabicyclo<4.4.0>dec-7-ene

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) MgSO₄, 2.) NaBH₄ / 1.) methylene dichloride, -23 dec C, 11 h, 2.) methylene dichloride, methanol, -63 deg C, 0.75 h

2: 94 percent / Et₃N / CH₂Cl₂ / 0.25 h / -23 °C

3: 94 percent / NaH, Pd(diphos)2 / 1,2-dimethoxy-ethane / 1.) 0 deg C, 40 min, 2.) 85 deg C, 10 min

4: 90.9 percent / Na₂HPO₄, (Na)Hg / methanol / 1 h / Ambient temperature

With sodium tetrahydroborate; disodium hydrogenphosphate; sodium amalgam; bis[1,2-bis(diphenylphosphino)ethane]palladium⁽⁰⁾; sodium hydride; magnesium sulfate; triethylamine; In methanol; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/jo00354a015