4-Benzyloxy-4'-biphenylcarbonyl chloride

Base Information

• Chemical Name: 4-Benzyloxy-4'-biphenylcarbonyl chloride
• CAS No.: 111153-17-4
• Molecular Formula: C₂₀H₁₅ClO₂
• Molecular Weight: 322.791
• DSSTox Substance ID: DTXSID001212864
• Mol file: 111153-17-4.mol

Synonyms:4-benzyloxy-4'-biphenylcarbonyl chloride;SCHEMBL8378881;RCZFWHNUXHJNPS-UHFFFAOYSA-N;DTXSID001212864;111153-17-4;4'-benzyloxybiphenyl-4-carboxylic chloride;4'-benzyloxybiphenyl-4-carboxylic acid chloride;4-benzyloxybiphenyl-4'-carboxylic acid chloride

Chemical Property of 4-Benzyloxy-4'-biphenylcarbonyl chloride

Chemical Property:

• XLogP3: 5.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 322.0760574
• Heavy Atom Count: 23
• Complexity: 362

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC=C(C=C2)C3=CC=C(C=C3)C(=O)Cl

Technology Process of 4-Benzyloxy-4'-biphenylcarbonyl chloride

There total 1 articles about 4-Benzyloxy-4'-biphenylcarbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4'-(Benzyloxy)-biphenyl-4-carboxylic acid (111153-16-3) → 4-benzyloxy-biphenyl-4'-carboxylic acid chloride (111153-17-4)

Guidance literature:

With thionyl chloride; for 1h; Heating;

DOI:10.1021/ja00174a023

Reference yield:

4-benzyloxy-biphenyl-4'-carboxylic acid chloride (111153-17-4) → 4'-(12-Acryloyloxy-dodecyloxy)-biphenyl-4-carboxylic acid 4-((R)-1-difluoromethyl-heptyloxycarbonyl)-phenyl ester (128055-25-4)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / CH₂Cl₂ / 72 h / Ambient temperature

2: 79 percent / H₂ / 10percent Pd/C / ethanol / 5 h / Irradiation

3: 1.) NaH / 1.) THF, RT, 2 h, 2.) 50 deg C, 5 h

With pyridine; hydrogen; sodium hydride; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/ja00174a023

Reference yield:

4-benzyloxy-biphenyl-4'-carboxylic acid chloride (111153-17-4) → 4'-[6-(2-Methyl-acryloyloxy)-hexyloxy]-biphenyl-4-carboxylic acid 4-((R)-1-trifluoromethyl-heptyloxycarbonyl)-phenyl ester (128055-27-6)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / CH₂Cl₂ / 72 h / Ambient temperature

2: 87 percent / H₂ / 10percent Pd/C / ethanol / 5 h / Irradiation

3: 1.) NaH / 1.) THF, RT, 2 h, 2.) 50 deg C, 5 h

With pyridine; hydrogen; sodium hydride; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/ja00174a023

upstream raw materials:

4'-(Benzyloxy)-biphenyl-4-carboxylic acid

Downstream raw materials:

(R)-(+)-4-<<<1-(difluoromethyl)heptyl>oxy>carbonyl>phenyl 4'-(benzyloxy)biphenyl-4-carboxylate

(S)-(-)-4-<<<1-(difluoromethyl)heptyl>oxy>carbonyl>phenyl 4'-(benzyloxy)biphenyl-4-carboxylate

(S)-(-)-4-<<<1-(trifluoromethyl)heptyl>oxy>carbonyl>phenyl 4'-(benzyloxy)biphenyl-4-carboxylate

(R)-(+)-4-<<<1-(trifluoromethyl)heptyl>oxy>carbonyl>phenyl-4'-(benzyloxy)biphenyl-4-carboxylate