2-(4-hydroxyphenyl)-3-benzyl-6-(morpholin-4-yl)-1,2,3,4-tetrahydro-1H-quinazolin-4-one

Base Information

Chemical Name:2-(4-hydroxyphenyl)-3-benzyl-6-(morpholin-4-yl)-1,2,3,4-tetrahydro-1H-quinazolin-4-one
CAS No.:1339011-36-7
Molecular Formula:C₂₅H₂₅N₃O₃
Molecular Weight:415.492
Hs Code.:

Synonyms:2-(4-hydroxyphenyl)-3-benzyl-6-(morpholin-4-yl)-1,2,3,4-tetrahydro-1H-quinazolin-4-one

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Chemical Property of 2-(4-hydroxyphenyl)-3-benzyl-6-(morpholin-4-yl)-1,2,3,4-tetrahydro-1H-quinazolin-4-one

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Technology Process of 2-(4-hydroxyphenyl)-3-benzyl-6-(morpholin-4-yl)-1,2,3,4-tetrahydro-1H-quinazolin-4-one

There total 5 articles about 2-(4-hydroxyphenyl)-3-benzyl-6-(morpholin-4-yl)-1,2,3,4-tetrahydro-1H-quinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.59%

: 1339011-06-1
N-benzyl-2-amino-5-(morpholin-4-yl)benzamide

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1339011-36-7
2-(4-hydroxyphenyl)-3-benzyl-6-(morpholin-4-yl)-1,2,3,4-tetrahydro-1H-quinazolin-4-one

Guidance literature:: With toluene-4-sulfonic acid; In N,N-dimethyl acetamide; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2011.07.029

Reference yield:

: 153437-51-5
2-nitro-5-(morpholin-4-yl)benzoic acid

: 1339011-36-7
2-(4-hydroxyphenyl)-3-benzyl-6-(morpholin-4-yl)-1,2,3,4-tetrahydro-1H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 0.17 h / 20 °C

1.2: 2 h / 20 °C

2.1: acetic acid; zinc / dichloromethane / 2 h / 20 °C

3.1: toluene-4-sulfonic acid / N,N-dimethyl acetamide / 2 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; toluene-4-sulfonic acid; acetic acid; triethylamine; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1016/j.bmc.2011.07.029

Reference yield:

: 941177-59-9
N-benzyl-2-nitro-5-(morpholin-4-yl)benzamide

: 1339011-36-7
2-(4-hydroxyphenyl)-3-benzyl-6-(morpholin-4-yl)-1,2,3,4-tetrahydro-1H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; zinc / dichloromethane / 2 h / 20 °C

2: toluene-4-sulfonic acid / N,N-dimethyl acetamide / 2 h / 20 °C

With toluene-4-sulfonic acid; acetic acid; zinc; In dichloromethane; N,N-dimethyl acetamide;
DOI:10.1016/j.bmc.2011.07.029