ethyl 2-methyl-2-{4-[({4'-[(trifluoromethyl)oxy]-4-biphenylyl}methyl)amino]-1-piperidinyl}propanoate

Base Information

Chemical Name:ethyl 2-methyl-2-{4-[({4'-[(trifluoromethyl)oxy]-4-biphenylyl}methyl)amino]-1-piperidinyl}propanoate
CAS No.:1018816-03-9
Molecular Formula:C₂₅H₃₁F₃N₂O₃
Molecular Weight:464.528
Hs Code.:

Synonyms:ethyl 2-methyl-2-{4-[({4'-[(trifluoromethyl)oxy]-4-biphenylyl}methyl)amino]-1-piperidinyl}propanoate

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Chemical Property of ethyl 2-methyl-2-{4-[({4'-[(trifluoromethyl)oxy]-4-biphenylyl}methyl)amino]-1-piperidinyl}propanoate

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Technology Process of ethyl 2-methyl-2-{4-[({4'-[(trifluoromethyl)oxy]-4-biphenylyl}methyl)amino]-1-piperidinyl}propanoate

There total 6 articles about ethyl 2-methyl-2-{4-[({4'-[(trifluoromethyl)oxy]-4-biphenylyl}methyl)amino]-1-piperidinyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (4′-trifluoromethoxybiphenyl-4-yl)methylammonium chloride

: 1018815-98-9
ethyl 2-methyl-2-(4-oxo-1-piperidinyl)propanoate

: 1018816-03-9
ethyl 2-methyl-2-{4-[({4'-[(trifluoromethyl)oxy]-4-biphenylyl}methyl)amino]-1-piperidinyl}propanoate

Guidance literature:: (4′-trifluoromethoxybiphenyl-4-yl)methylammonium chloride; ethyl 2-methyl-2-(4-oxo-1-piperidinyl)propanoate; With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 3h;

With sodium carbonate; In water; 1,2-dichloro-ethane; for 0.75h;

Reference yield:

: 1018815-98-9
ethyl 2-methyl-2-(4-oxo-1-piperidinyl)propanoate

: ({4'-[(trifluoromethyl)oxy]-4-biphenylyl}methyl)amine hydrochloride

: 1018816-03-9
ethyl 2-methyl-2-{4-[({4'-[(trifluoromethyl)oxy]-4-biphenylyl}methyl)amino]-1-piperidinyl}propanoate

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 157788-40-4
4'-(trifluoromethoxy)-[1,1'-biphenyl]-4-carbonitrile

: 1018816-03-9
ethyl 2-methyl-2-{4-[({4'-[(trifluoromethyl)oxy]-4-biphenylyl}methyl)amino]-1-piperidinyl}propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; hydrogen; 10 wt% Pd(OH)2 on carbon / ethanol; water / 1292.9 Torr

2: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; 10 wt% Pd(OH)2 on carbon; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; In ethanol; water; 1,2-dichloro-ethane;