(1R,2S)-1-{[trans-2-{1-[((S)-cyclohexyl(methoxycarbonyl)methyl)carbamoyl]-2,2-dimethylpropylcarbamoyl}-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-2-enecarbonyl]amino}-2-vinylcyclopropanecarboxylic acid tert-butyl ester

Base Information

Chemical Name:(1R,2S)-1-{[trans-2-{1-[((S)-cyclohexyl(methoxycarbonyl)methyl)carbamoyl]-2,2-dimethylpropylcarbamoyl}-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-2-enecarbonyl]amino}-2-vinylcyclopropanecarboxylic acid tert-butyl ester
CAS No.:959346-16-8
Molecular Formula:C₄₈H₆₁N₅O₈
Molecular Weight:836.041
Hs Code.:

(1R,2S)-1-{[trans-2-{1-[((S)-cyclohexyl(methoxycarbonyl)methyl)carbamoyl]-2,2-dimethylpropylcarbamoyl}-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-2-enecarbonyl]amino}-2-vinylcyclopropanecarboxylic acid tert-butyl ester

Synonyms:(1R,2S)-1-{[trans-2-{1-[((S)-cyclohexyl(methoxycarbonyl)methyl)carbamoyl]-2,2-dimethylpropylcarbamoyl}-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-2-enecarbonyl]amino}-2-vinylcyclopropanecarboxylic acid tert-butyl ester

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Chemical Property of (1R,2S)-1-{[trans-2-{1-[((S)-cyclohexyl(methoxycarbonyl)methyl)carbamoyl]-2,2-dimethylpropylcarbamoyl}-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-2-enecarbonyl]amino}-2-vinylcyclopropanecarboxylic acid tert-butyl ester

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Technology Process of (1R,2S)-1-{[trans-2-{1-[((S)-cyclohexyl(methoxycarbonyl)methyl)carbamoyl]-2,2-dimethylpropylcarbamoyl}-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-2-enecarbonyl]amino}-2-vinylcyclopropanecarboxylic acid tert-butyl ester

There total 8 articles about (1R,2S)-1-{[trans-2-{1-[((S)-cyclohexyl(methoxycarbonyl)methyl)carbamoyl]-2,2-dimethylpropylcarbamoyl}-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-2-enecarbonyl]amino}-2-vinylcyclopropanecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 862119-02-6
(S)-2-amino-N-((S)-cyclohexyl(methylcarbamoyl)methyl)-3,3-dimethylbutyramide

: 862247-48-1
trans-5-[((1R,2S)-1-tert-butoxycarbonyl-1-vinylcyclopropyl)carbamoyl]-3-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-1-enecarboxylic acid

: 959346-16-8
(1R,2S)-1-{[trans-2-{1-[((S)-cyclohexyl(methoxycarbonyl)methyl)carbamoyl]-2,2-dimethylpropylcarbamoyl}-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-2-enecarbonyl]amino}-2-vinylcyclopropanecarboxylic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 ℃;
DOI:10.1016/j.bmc.2006.10.044

Reference yield:

: 862119-00-4
(S)-((S)-2-tert-butoxycarbonylamino-3,3-dimethylbutyrylamino)cyclohexylacetic acid methyl ester

: 959346-16-8
(1R,2S)-1-{[trans-2-{1-[((S)-cyclohexyl(methoxycarbonyl)methyl)carbamoyl]-2,2-dimethylpropylcarbamoyl}-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-2-enecarbonyl]amino}-2-vinylcyclopropanecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq. LiOH / dioxane / 4 h / cooling

1.2: 0.29 g / O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium PF₆; ethyldiisopropylamine / dimethylformamide / 3 h / cooling

2.1: 95 percent / triethylsilane; trifluoroacetic acid / CH₂Cl₂ / 3 h

3.1: 60 percent / O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium PF₆; ethyldiisopropylamine / dimethylformamide / 0 °C

With triethylsilane; lithium hydroxide; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.10.044

Reference yield:

: 862118-90-9
tert-butyl (S)-1-((S)-(methylcarbamoyl)(cyclohexyl)methylcarbamoyl)-2,2-dimethylpropylcarbamate

: 959346-16-8
(1R,2S)-1-{[trans-2-{1-[((S)-cyclohexyl(methoxycarbonyl)methyl)carbamoyl]-2,2-dimethylpropylcarbamoyl}-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-2-enecarbonyl]amino}-2-vinylcyclopropanecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / triethylsilane; trifluoroacetic acid / CH₂Cl₂ / 3 h

2: 60 percent / O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium PF₆; ethyldiisopropylamine / dimethylformamide / 0 °C

With triethylsilane; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.10.044