Technology Process of (E)-4-((1s,4s)-4-azidocyclohexyl)-2-methylbut-2-enal
There total 7 articles about (E)-4-((1s,4s)-4-azidocyclohexyl)-2-methylbut-2-enal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine; Dess-Martin periodane;
In
dichloromethane;
at 0 - 20 ℃;
for 2h;
DOI:10.1021/jm401370h
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: borane-THF / tetrahydrofuran / 4 h / 0 - 20 °C
2.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Cooling with ice
3.1: potassium carbonate; copper(ll) sulfate pentahydrate; imidazole-1-sulfonyl azide hydrochloride / methanol / 20 °C / Cooling with ice
4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C
4.2: 1 h / 20 °C
5.1: 0.17 h / 20 °C / Cooling with ice
6.1: diisobutylaluminium hydride / dichloromethane; hexane / 2.5 h / -78 °C
7.1: pyridine; Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C
With
pyridine; imidazole-1-sulfonyl azide hydrochloride; copper(ll) sulfate pentahydrate; borane-THF; oxalyl dichloride; diisobutylaluminium hydride; potassium carbonate; Dess-Martin periodane; dimethyl sulfoxide; trifluoroacetic acid;
In
tetrahydrofuran; methanol; hexane; dichloromethane;
4.1: |Swern Oxidation / 4.2: |Swern Oxidation;
DOI:10.1021/jm401370h
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate; copper(ll) sulfate pentahydrate; imidazole-1-sulfonyl azide hydrochloride / methanol / 20 °C / Cooling with ice
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C
2.2: 1 h / 20 °C
3.1: 0.17 h / 20 °C / Cooling with ice
4.1: diisobutylaluminium hydride / dichloromethane; hexane / 2.5 h / -78 °C
5.1: pyridine; Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C
With
pyridine; imidazole-1-sulfonyl azide hydrochloride; copper(ll) sulfate pentahydrate; oxalyl dichloride; diisobutylaluminium hydride; potassium carbonate; Dess-Martin periodane; dimethyl sulfoxide;
In
methanol; hexane; dichloromethane;
2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1021/jm401370h
