(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-[(3S)-morpholin-3-ylmethyl]-1,3-thiazolidine-2,4-dione

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Chemical Name:(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-[(3S)-morpholin-3-ylmethyl]-1,3-thiazolidine-2,4-dione
CAS No.:1351567-71-9
Molecular Formula:C₂₄H₂₀ClF₃N₄O₃S
Molecular Weight:536.962
Hs Code.:

Synonyms:(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-[(3S)-morpholin-3-ylmethyl]-1,3-thiazolidine-2,4-dione

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Chemical Property of (5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-[(3S)-morpholin-3-ylmethyl]-1,3-thiazolidine-2,4-dione

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Technology Process of (5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-[(3S)-morpholin-3-ylmethyl]-1,3-thiazolidine-2,4-dione

There total 2 articles about (5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-[(3S)-morpholin-3-ylmethyl]-1,3-thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

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: 714971-28-5
(S)-3-(hydroxymethyl)morpholine-4-carboxylic acid tert-butyl ester

: 1351566-94-3
(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-piperidin-4-yl-1,3-thiazolidine-2,4-dione

: 1351567-71-9
(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-[(3S)-morpholin-3-ylmethyl]-1,3-thiazolidine-2,4-dione

Guidance literature:: (S)-3-(hydroxymethyl)morpholine-4-carboxylic acid tert-butyl ester; (5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-piperidin-4-yl-1,3-thiazolidine-2,4-dione; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 40h; Cooling with ice;

With trifluoroacetic acid; In dichloromethane; for 1h;
DOI:10.1016/j.ejmech.2017.07.015