2-[2-((S)-5-Amino-6-hydroxy-hexyl)-benzyl]-malonic acid monomethyl ester

Base Information

Chemical Name:2-[2-((S)-5-Amino-6-hydroxy-hexyl)-benzyl]-malonic acid monomethyl ester
CAS No.:1026853-97-3
Molecular Formula:C₁₇H₂₅NO₅
Molecular Weight:323.389
Hs Code.:

Synonyms:2-[2-((S)-5-Amino-6-hydroxy-hexyl)-benzyl]-malonic acid monomethyl ester

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Chemical Property of 2-[2-((S)-5-Amino-6-hydroxy-hexyl)-benzyl]-malonic acid monomethyl ester

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Technology Process of 2-[2-((S)-5-Amino-6-hydroxy-hexyl)-benzyl]-malonic acid monomethyl ester

There total 10 articles about 2-[2-((S)-5-Amino-6-hydroxy-hexyl)-benzyl]-malonic acid monomethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136923-04-1
tert-butyl (4S)-4-(3-hydroxypropyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

: 1026853-97-3
2-[2-((S)-5-Amino-6-hydroxy-hexyl)-benzyl]-malonic acid monomethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: pyridinium chlorochromate / CH₂Cl₂

2: t-BuOK / CH₂Cl₂; tetrahydrofuran / 0.5 h / 0 °C

3: n-BuLi / tetrahydrofuran / 1 h / -78 - 0 °C

4: piperidine, benzoic acid / toluene / 6 h / Heating

5: H₂ / 10percent Pd/C / ethyl acetate / 17 h / 2585.7 Torr

6: HCl (gas) / CH₂Cl₂ / Ambient temperature

With piperidine; hydrogenchloride; n-butyllithium; potassium tert-butylate; hydrogen; benzoic acid; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene;
DOI:10.1021/jm960582o

Reference yield:

: 36901-75-4
(2-bromobenzyl)triphenylphosphonium bromide

: 1026853-97-3
2-[2-((S)-5-Amino-6-hydroxy-hexyl)-benzyl]-malonic acid monomethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: t-BuOK / CH₂Cl₂; tetrahydrofuran / 0.5 h / 0 °C

2: n-BuLi / tetrahydrofuran / 1 h / -78 - 0 °C

3: piperidine, benzoic acid / toluene / 6 h / Heating

4: H₂ / 10percent Pd/C / ethyl acetate / 17 h / 2585.7 Torr

5: HCl (gas) / CH₂Cl₂ / Ambient temperature

With piperidine; hydrogenchloride; n-butyllithium; potassium tert-butylate; hydrogen; benzoic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene;
DOI:10.1021/jm960582o

Reference yield:

: 144090-56-2
2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-4(S)-oxazolidinepropanal

: 1026853-97-3
2-[2-((S)-5-Amino-6-hydroxy-hexyl)-benzyl]-malonic acid monomethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: t-BuOK / CH₂Cl₂; tetrahydrofuran / 0.5 h / 0 °C

2: n-BuLi / tetrahydrofuran / 1 h / -78 - 0 °C

3: piperidine, benzoic acid / toluene / 6 h / Heating

4: H₂ / 10percent Pd/C / ethyl acetate / 17 h / 2585.7 Torr

5: HCl (gas) / CH₂Cl₂ / Ambient temperature

With piperidine; hydrogenchloride; n-butyllithium; potassium tert-butylate; hydrogen; benzoic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene;
DOI:10.1021/jm960582o