7-chloro-5-(2-fluoro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

Base Information

Chemical Name:7-chloro-5-(2-fluoro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one
CAS No.:36811-66-2
Molecular Formula:C₁₃H₈ClFN₂OS
Molecular Weight:294.737
Hs Code.:

7-chloro-5-(2-fluoro-phenyl)-1,3-dihydro-thieno[2,3-<i>e</i>][1,4]diazepin-2-one

Synonyms:7-chloro-5-(2-fluoro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-chloro-5-(2-fluoro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

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Technology Process of 7-chloro-5-(2-fluoro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

There total 17 articles about 7-chloro-5-(2-fluoro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 36811-60-6
5-(2-fluoro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

: 36811-66-2
7-chloro-5-(2-fluoro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

Guidance literature:: With sulfuryl dichloride; In acetic acid; for 4h; Ambient temperature;
DOI:10.1002/ardp.19803130704

Reference yield: 32.0%

: 55985-58-5
2-Amino-N-[5-chloro-3-(2-fluoro-benzoyl)-thiophen-2-yl]-acetamide

: 36811-66-2
7-chloro-5-(2-fluoro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

Guidance literature:: With sulfuryl dichloride; In acetic acid; for 4h; Ambient temperature;
DOI:10.1002/ardp.19803130704

Reference yield:

: 40017-70-7
2-Amino-3-(2-fluorbenzoyl)-thiophen

: 36811-66-2
7-chloro-5-(2-fluoro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / dioxane / 2 h / Ambient temperature

2: NaI / acetone / 1 h / Heating

3: 71 percent / conc. aq. NH₃ / CH₂Cl₂ / 60 h / Ambient temperature

4: 89 percent / acetic acid / 0.25 h / Heating

5: 77 percent / SO₂Cl₂ / acetic acid / 4 h / Ambient temperature

With ammonium hydroxide; sulfuryl dichloride; potassium carbonate; acetic acid; sodium iodide; In 1,4-dioxane; dichloromethane; acetic acid; acetone;
DOI:10.1002/ardp.19803130704