2'-fluoro-biphenyl-4-carboxylic acid N-(4-{2-[(3-anthracen-9-yl-propyl)-methylamino]-ethoxy}-2-[1,3]dioxan-2-ylmethyl-phenyl)-amide

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Chemical Name:2'-fluoro-biphenyl-4-carboxylic acid N-(4-{2-[(3-anthracen-9-yl-propyl)-methylamino]-ethoxy}-2-[1,3]dioxan-2-ylmethyl-phenyl)-amide
CAS No.:705961-63-3
Molecular Formula:C₄₄H₄₃FN₂O₄
Molecular Weight:682.835
Hs Code.:

Synonyms:2'-fluoro-biphenyl-4-carboxylic acid N-(4-{2-[(3-anthracen-9-yl-propyl)-methylamino]-ethoxy}-2-[1,3]dioxan-2-ylmethyl-phenyl)-amide

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Chemical Property of 2'-fluoro-biphenyl-4-carboxylic acid N-(4-{2-[(3-anthracen-9-yl-propyl)-methylamino]-ethoxy}-2-[1,3]dioxan-2-ylmethyl-phenyl)-amide

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Technology Process of 2'-fluoro-biphenyl-4-carboxylic acid N-(4-{2-[(3-anthracen-9-yl-propyl)-methylamino]-ethoxy}-2-[1,3]dioxan-2-ylmethyl-phenyl)-amide

There total 14 articles about 2'-fluoro-biphenyl-4-carboxylic acid N-(4-{2-[(3-anthracen-9-yl-propyl)-methylamino]-ethoxy}-2-[1,3]dioxan-2-ylmethyl-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1993-03-9
o-fluorophenylboronic acid

: 705961-59-7
N-(4-{2-[(3-anthracen-9-yl-propyl)-methylamino]-ethoxy}-2-[1,3]dioxan-2-ylmethyl-phenyl)-4-bromobenzamide

: 705961-63-3
2'-fluoro-biphenyl-4-carboxylic acid N-(4-{2-[(3-anthracen-9-yl-propyl)-methylamino]-ethoxy}-2-[1,3]dioxan-2-ylmethyl-phenyl)-amide

Guidance literature:: With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 80 ℃; for 0.5h;
DOI:10.1039/b400110a

Reference yield:

: 2581-34-2,910311-23-8
3-methyl-4-nitrophenol

: 705961-63-3
2'-fluoro-biphenyl-4-carboxylic acid N-(4-{2-[(3-anthracen-9-yl-propyl)-methylamino]-ethoxy}-2-[1,3]dioxan-2-ylmethyl-phenyl)-amide

Guidance literature:: Multi-step reaction with 12 steps

1.1: 91 percent / K₂CO₃ / dimethylformamide / 2 h / 90 °C

2.1: dimethylformamide / 24 h / Heating

2.2: 82 percent / aq. HCl / diethyl ether / 2 h / Heating

3.1: 93 percent / trifluoroacetic acid / 24 h / 20 °C

4.1: 92 percent / Amberlyst H-15 / CH₂Cl₂ / 16 h / 20 °C

5.1: 98 percent / K₂CO₃ / dimethylformamide / 2 h / 90 °C

6.1: 98 percent / Amberlyst H-15 / tetrahydrofuran / 24 h / 20 °C

7.1: 89 percent / NaBH₄; iodine / tetrahydrofuran / 4 h / Heating

8.1: 93 percent / Et₃N / CH₂Cl₂ / 2 h / 20 °C

9.1: 89 percent / NaBH₄ / copper acetylacetonate / CH₂Cl₂; propan-2-ol; methanol / 0.5 h / Heating

10.1: 90 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 16 h / 20 °C

11.1: 1-hydroxybenzotriazole; diisopropylcarbodiimide / dimethylformamide / 0.25 h / 20 °C

11.2: dimethylformamide / 2 h / 20 °C

12.1: 84 percent / Cs₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 0.5 h / 80 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; Amberlyst H-15; iodine; potassium carbonate; benzotriazol-1-ol; caesium carbonate; triethylamine; trifluoroacetic acid; diisopropyl-carbodiimide; copper acetylacetonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; 12.1: Suzuki coupling;
DOI:10.1039/b400110a

Reference yield:

: 22424-58-4
5-benzyloxy-2-nitrotoluene

: 705961-63-3
2'-fluoro-biphenyl-4-carboxylic acid N-(4-{2-[(3-anthracen-9-yl-propyl)-methylamino]-ethoxy}-2-[1,3]dioxan-2-ylmethyl-phenyl)-amide

Guidance literature:: Multi-step reaction with 11 steps

1.1: dimethylformamide / 24 h / Heating

1.2: 82 percent / aq. HCl / diethyl ether / 2 h / Heating

2.1: 93 percent / trifluoroacetic acid / 24 h / 20 °C

3.1: 92 percent / Amberlyst H-15 / CH₂Cl₂ / 16 h / 20 °C

4.1: 98 percent / K₂CO₃ / dimethylformamide / 2 h / 90 °C

5.1: 98 percent / Amberlyst H-15 / tetrahydrofuran / 24 h / 20 °C

6.1: 89 percent / NaBH₄; iodine / tetrahydrofuran / 4 h / Heating

7.1: 93 percent / Et₃N / CH₂Cl₂ / 2 h / 20 °C

8.1: 89 percent / NaBH₄ / copper acetylacetonate / CH₂Cl₂; propan-2-ol; methanol / 0.5 h / Heating

9.1: 90 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 16 h / 20 °C

10.1: 1-hydroxybenzotriazole; diisopropylcarbodiimide / dimethylformamide / 0.25 h / 20 °C

10.2: dimethylformamide / 2 h / 20 °C

11.1: 84 percent / Cs₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 0.5 h / 80 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; Amberlyst H-15; iodine; potassium carbonate; benzotriazol-1-ol; caesium carbonate; triethylamine; trifluoroacetic acid; diisopropyl-carbodiimide; copper acetylacetonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; 11.1: Suzuki coupling;
DOI:10.1039/b400110a