3-[4-(1-{4-[3-fluoro-4-(methylsulfonyl)phenyl]-1,3-oxazol-2-yl}propoxy)phenyl]-5-isopropyl-1,2,4-oxadiazole

Base Information

Chemical Name:3-[4-(1-{4-[3-fluoro-4-(methylsulfonyl)phenyl]-1,3-oxazol-2-yl}propoxy)phenyl]-5-isopropyl-1,2,4-oxadiazole
CAS No.:1263320-72-4
Molecular Formula:C₂₄H₂₄FN₃O₅S
Molecular Weight:485.536
Hs Code.:

Synonyms:3-[4-(1-{4-[3-fluoro-4-(methylsulfonyl)phenyl]-1,3-oxazol-2-yl}propoxy)phenyl]-5-isopropyl-1,2,4-oxadiazole

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Chemical Property of 3-[4-(1-{4-[3-fluoro-4-(methylsulfonyl)phenyl]-1,3-oxazol-2-yl}propoxy)phenyl]-5-isopropyl-1,2,4-oxadiazole

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Technology Process of 3-[4-(1-{4-[3-fluoro-4-(methylsulfonyl)phenyl]-1,3-oxazol-2-yl}propoxy)phenyl]-5-isopropyl-1,2,4-oxadiazole

There total 9 articles about 3-[4-(1-{4-[3-fluoro-4-(methylsulfonyl)phenyl]-1,3-oxazol-2-yl}propoxy)phenyl]-5-isopropyl-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1263320-64-4
3-[4-(1-{4-[3-Fluoro-4-(methylthio)phenyl]-1,3-oxazol-2-yl}propoxy)phenyl]-5-isopropyl-1,2,4-oxadiazole

: 1263320-72-4
3-[4-(1-{4-[3-fluoro-4-(methylsulfonyl)phenyl]-1,3-oxazol-2-yl}propoxy)phenyl]-5-isopropyl-1,2,4-oxadiazole

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 13.25h; Cooling with ice;

Reference yield:

: 767-00-0
4-cyanophenol

: 1263320-72-4
3-[4-(1-{4-[3-fluoro-4-(methylsulfonyl)phenyl]-1,3-oxazol-2-yl}propoxy)phenyl]-5-isopropyl-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / acetonitrile / 3 h / 80 °C

2: hydroxylamine / ethanol; water / 2.5 h / 80 °C

3: pyridine / 2 h / 100 °C

4: sodium hydroxide; water / tetrahydrofuran; methanol / 0.5 h / 20 °C

5: triethylamine / water; acetone / 0.5 h / 20 °C

6: 2,2,2-trifluoroacetic acid ammonia / 4 h / 150 °C

7: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 13.25 h / 20 °C / Cooling with ice

With pyridine; water; hydroxylamine; 2,2,2-trifluoroacetic acid ammonia; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetone; acetonitrile;

Reference yield:

: 709-68-2
2-bromo-1-(3-fluoro-4-(methylthio)phenyl) ethanone

: 1263320-72-4
3-[4-(1-{4-[3-fluoro-4-(methylsulfonyl)phenyl]-1,3-oxazol-2-yl}propoxy)phenyl]-5-isopropyl-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / water; acetone / 0.5 h / 20 °C

2: 2,2,2-trifluoroacetic acid ammonia / 4 h / 150 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 13.25 h / 20 °C / Cooling with ice

With 2,2,2-trifluoroacetic acid ammonia; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water; acetone;