(S)-5,5-dimethyl-3-((1r,4S)-4-(2-oxo-1H-imidazo[4,5-c]pyridin-3(2H)-yl)cyclohexyl)-4-phenyloxazolidin-2-one

Base Information

Chemical Name:(S)-5,5-dimethyl-3-((1r,4S)-4-(2-oxo-1H-imidazo[4,5-c]pyridin-3(2H)-yl)cyclohexyl)-4-phenyloxazolidin-2-one
CAS No.:1437789-98-4
Molecular Formula:C₂₃H₂₆N₄O₃
Molecular Weight:406.484
Hs Code.:

Synonyms:(S)-5,5-dimethyl-3-((1r,4S)-4-(2-oxo-1H-imidazo[4,5-c]pyridin-3(2H)-yl)cyclohexyl)-4-phenyloxazolidin-2-one

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Chemical Property of (S)-5,5-dimethyl-3-((1r,4S)-4-(2-oxo-1H-imidazo[4,5-c]pyridin-3(2H)-yl)cyclohexyl)-4-phenyloxazolidin-2-one

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Technology Process of (S)-5,5-dimethyl-3-((1r,4S)-4-(2-oxo-1H-imidazo[4,5-c]pyridin-3(2H)-yl)cyclohexyl)-4-phenyloxazolidin-2-one

There total 10 articles about (S)-5,5-dimethyl-3-((1r,4S)-4-(2-oxo-1H-imidazo[4,5-c]pyridin-3(2H)-yl)cyclohexyl)-4-phenyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.81%

: 1437789-97-3
3-(((1S,4r)-4-((S)-5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)cyclohexyl)amino)isonicotinic acid

: 1437789-98-4
(S)-5,5-dimethyl-3-((1r,4S)-4-(2-oxo-1H-imidazo[4,5-c]pyridin-3(2H)-yl)cyclohexyl)-4-phenyloxazolidin-2-one

Guidance literature:: With diphenylphosphoranyl azide; triethylamine; In tetrahydrofuran; at 80 ℃;

Reference yield:

: 1437790-21-0
methyl 3-(((1S,4r)-4-((S)-5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)cyclohexyl)amino)isonicotinate

: 1437789-98-4
(S)-5,5-dimethyl-3-((1r,4S)-4-(2-oxo-1H-imidazo[4,5-c]pyridin-3(2H)-yl)cyclohexyl)-4-phenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / methanol; tetrahydrofuran / 2 h / 50 °C

2: triethylamine; diphenylphosphoranyl azide / tetrahydrofuran / 80 °C

With diphenylphosphoranyl azide; water; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1021/jm4000038

Reference yield:

: 15028-39-4,13226-98-7
L-2-phenylglycine methyl ester hydrochloride

: 1437789-98-4
(S)-5,5-dimethyl-3-((1r,4S)-4-(2-oxo-1H-imidazo[4,5-c]pyridin-3(2H)-yl)cyclohexyl)-4-phenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1,2-dichloro-ethane / 0.25 h / 20 °C

1.2: 20 °C

2.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

5.1: triethylamine / acetonitrile / 80 °C / Sealed tube

6.1: water; lithium hydroxide / methanol; tetrahydrofuran / 2 h / 50 °C

7.1: triethylamine; diphenylphosphoranyl azide / tetrahydrofuran / 80 °C

With diphenylphosphoranyl azide; water; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/jm4000038