tert-butyl 6-((tert-butyldiphenylsilyl)oxy)-3-cyclobutyl-1H-indazole-1-carboxylate

Base Information

Chemical Name:tert-butyl 6-((tert-butyldiphenylsilyl)oxy)-3-cyclobutyl-1H-indazole-1-carboxylate
CAS No.:1221235-57-9
Molecular Formula:C₃₂H₃₈N₂O₃Si
Molecular Weight:526.751
Hs Code.:

Synonyms:tert-butyl 6-((tert-butyldiphenylsilyl)oxy)-3-cyclobutyl-1H-indazole-1-carboxylate

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Chemical Property of tert-butyl 6-((tert-butyldiphenylsilyl)oxy)-3-cyclobutyl-1H-indazole-1-carboxylate

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Technology Process of tert-butyl 6-((tert-butyldiphenylsilyl)oxy)-3-cyclobutyl-1H-indazole-1-carboxylate

There total 8 articles about tert-butyl 6-((tert-butyldiphenylsilyl)oxy)-3-cyclobutyl-1H-indazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1221235-56-8
6-((tert-butyldiphenylsilyl)oxy)-3-cyclobutyl-1H-indazole

: 1221235-57-9
tert-butyl 6-((tert-butyldiphenylsilyl)oxy)-3-cyclobutyl-1H-indazole-1-carboxylate

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; for 4h;

Reference yield:

: 82380-18-5
2-fluoro-4-hydroxybenzonitrile

: 1221235-57-9
tert-butyl 6-((tert-butyldiphenylsilyl)oxy)-3-cyclobutyl-1H-indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

2.1: magnesium / iodine / diethyl ether; tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C

2.3: copper bromide / 0.5 h / Reflux

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 20 °C

4.1: sodium acetate / xylene / Reflux; Dean-Stark apparatus

5.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 1.5 h / 60 °C

6.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

7.1: triethylamine / dmap / tetrahydrofuran / 4 h / 20 °C

With 1H-imidazole; hydrogenchloride; tetrabutyl ammonium fluoride; hydrogen; sodium acetate; magnesium; triethylamine; dmap; palladium 10% on activated carbon; iodine; In tetrahydrofuran; diethyl ether; ethanol; water; N,N-dimethyl-formamide; xylene;

Reference yield:

: 175968-15-7
4-((tert-butyldimethylsilyl)oxy)-2-fluorobenzonitrile

: 1221235-57-9
tert-butyl 6-((tert-butyldiphenylsilyl)oxy)-3-cyclobutyl-1H-indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: magnesium / iodine / diethyl ether; tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C

1.3: copper bromide / 0.5 h / Reflux

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 20 °C

3.1: sodium acetate / xylene / Reflux; Dean-Stark apparatus

4.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 1.5 h / 60 °C

5.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

6.1: triethylamine / dmap / tetrahydrofuran / 4 h / 20 °C

With 1H-imidazole; hydrogenchloride; tetrabutyl ammonium fluoride; hydrogen; sodium acetate; magnesium; triethylamine; dmap; palladium 10% on activated carbon; iodine; In tetrahydrofuran; diethyl ether; ethanol; water; N,N-dimethyl-formamide; xylene;