Pipofezine

Base Information

Chemical Name:Pipofezine
CAS No.:24886-52-0
Molecular Formula:C₁₆H₁₉N₅O
Molecular Weight:297.36
Hs Code.:2934999090
UNII:P8T739L1FA
DSSTox Substance ID:DTXSID5046271
Nikkaji Number:J34.309I
Wikipedia:Pipofezine
Wikidata:Q4363230
NCI Thesaurus Code:C66403
ChEMBL ID:CHEMBL1886755
Mol file:24886-52-0.mol

Synonyms:Pipofezine;24886-52-0;5-Methyl-3-(4-methylpiperazin-1-yl)-5H-benzo[b]pyridazino[4,3-e][1,4]oxazine;5-Methyl-3-(4-methyl-1-piperazinyl)-5H-pyridazino[3,4-b][1,4]benzoxazine;Pipofezine [INN];5-methyl-3-(4-methylpiperazin-1-yl)pyridazino[3,4-b][1,4]benzoxazine;UNII-P8T739L1FA;P8T739L1FA;DTXSID5046271;NCGC00160646-01;5-methyl-3-(4-methylpiperazin-1-yl)-5H-pyridazino[3,4-b][1,4]benzoxazine;DTXCID3026271;5-Methyl-3-(4-methyl-1-piperazinyl)-5H-pyridazino(3,4-b)(1,4)benzoxazine;CAS-24886-52-0;5H-Pyridazino[3,4-b][1,4]benzoxazine, 5-methyl-3-(4-methyl-1-piperazinyl)-;MFCD00409223;PIPOFEZINE [WHO-DD];Oprea1_716415;CBDivE_006387;SCHEMBL366226;CHEMBL1886755;CS-D0905;Tox21_111953;STK012259;AKOS005267147;Tox21_111953_1;CCG-103100;NCGC00160646-02;AS-10686;FT-0682993;A854192;SR-01000883689;Q4363230;SR-01000883689-1;5-methyl-3-(4-methylpiperazino)-5H-pyridazino[3,4-b][1,4]benzoxazine;5-Methyl-3-(4-methylpiperazinyl)-5H-pyridazino[4,3-b][1,4]benzoxazine;5H-PYRIDAZINO(3,4-B)(1,4)BENZOXAZINE, 5-METHYL-3-(4-METHYL-1-PIPERAZINYL)-;5H-yridazino[3,4-]1,4]enzoxazine, 5-ethyl-3-(4-ethyl-1-iperazinyl)-

Suppliers and Price of Pipofezine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
5-Methyl-3-(4-methyl-1-piperazinyl)-5H-pyridazino[3,4-b][1,4]benzoxazine
1g
$ 1446.00

Matrix Scientific
5-Methyl-3-(4-methyl-1-piperazinyl)-5H-pyridazino[3,4-b][1,4]benzoxazine
500mg
$ 940.00

Crysdot
5-Methyl-3-(4-methylpiperazin-1-yl)-5H-benzo[b]pyridazino[4,3-e][1,4]oxazine 95+%
1g
$ 432.00

Aronis compounds
5-methyl-3-(4-methyl-1-piperazinyl)-5H-pyridazino[3,4-b][1,4]benzoxazine
10g
$ 511.00

American Custom Chemicals Corporation
5-METHYL-3-(4-METHYL-1-PIPERAZINYL)-5H-PYRIDAZINO[3,4-B][1,4]BENZOXAZINE 95.00%
5MG
$ 497.00

AK Scientific
Pipofezine
25mg
$ 149.00

AK Scientific
Pipofezine
5mg
$ 48.90

Total 22 raw suppliers

Chemical Property of Pipofezine

Chemical Property:

Vapor Pressure:1.46E-11mmHg at 25°C
Boiling Point:536°Cat760mmHg
PKA:10.99±0.20(Predicted)
Flash Point:278°C
PSA：44.73000
Density:1.249g/cm³
LogP:2.16990
Storage Temp.:2-8°C
XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:297.15896025
Heavy Atom Count:22
Complexity:387

Purity/Quality:

97% ^*data from raw suppliers

5-Methyl-3-(4-methyl-1-piperazinyl)-5H-pyridazino[3,4-b][1,4]benzoxazine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCN(CC1)C2=NN=C3C(=C2)N(C4=CC=CC=C4O3)C
Uses PIPOFEZINE (cas# 24886-52-0) is used for investigating potential role of Brain-?derived neurotrophic factor and Prolactin genotypes on antidepressant response in depression patients.

Technology Process of Pipofezine

There total 2 articles about Pipofezine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-01-3
1-methyl-piperazine

: 27225-84-9
3-chloro-5-methyl-5H-benzo[b]pyridazino[4,3-e][1,4]oxazine

: 24886-52-0
pipofezine

Guidance literature:: With cyclohexanol; Heating;
DOI:10.1007/BF00477373

Reference yield:

: 24886-52-0
pipofezine

Guidance literature:: Diazaphenoxazin VI, 1) 1-Methyl-piperazin*2HCl, 2) NaOH;
DOI:10.1007/BF00771491

Reference yield:

: 24886-52-0
pipofezine

: 61939-77-3
1-[5-methyl-3-(4-methyl-piperazin-1-yl)-5H-benzo[b]pyridazino[4,3-e][1,4]oxazin-8-yl]-3-phenyl-thiourea

Guidance literature:: Multi-step reaction with 3 steps

1: (i) HNO₃, (ii) aq. NaOH

2: N₂H₄*H₂O / Raney-Ni / methanol / Heating

3: benzene / Heating

With hydrazine hydrate; nickel; In methanol; benzene;
DOI:10.1007/BF00758093