(2S,5S)-5-<(tert-Butyldiphenylsiloxy)methyl>tetrahydrofuran-2-carboxaldehyde

Base Information

Chemical Name:(2S,5S)-5-<(tert-Butyldiphenylsiloxy)methyl>tetrahydrofuran-2-carboxaldehyde
CAS No.:149099-14-9
Molecular Formula:C₂₂H₂₈O₃Si
Molecular Weight:368.548
Hs Code.:

Synonyms:(2S,5S)-5-<(tert-Butyldiphenylsiloxy)methyl>tetrahydrofuran-2-carboxaldehyde

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Chemical Property of (2S,5S)-5-<(tert-Butyldiphenylsiloxy)methyl>tetrahydrofuran-2-carboxaldehyde

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Technology Process of (2S,5S)-5-<(tert-Butyldiphenylsiloxy)methyl>tetrahydrofuran-2-carboxaldehyde

There total 14 articles about (2S,5S)-5-<(tert-Butyldiphenylsiloxy)methyl>tetrahydrofuran-2-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 165876-55-1
(2S,5S)-5-<(tert-butyldiphenylsiloxy)methyl>tetrahydrofuran-2-methanol

: 149099-14-9
(2S,5S)-5-<(tert-Butyldiphenylsiloxy)methyl>tetrahydrofuran-2-carboxaldehyde

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 1h;

Reference yield: 86.0%

: 170305-51-8
Methyl (2S,5S)-5-<(tert-Butyldiphenylsiloxy)methyl>tetrahydrofuran-2-carboxylate

: 149099-14-9
(2S,5S)-5-<(tert-Butyldiphenylsiloxy)methyl>tetrahydrofuran-2-carboxaldehyde

Guidance literature:: With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃; for 0.166667h;

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 149099-14-9
(2S,5S)-5-<(tert-Butyldiphenylsiloxy)methyl>tetrahydrofuran-2-carboxaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 46 percent / imidazole / acetonitrile; tetrahydrofuran / 1 h / -78 °C

2: 96 percent / hydrogen / Pd/C / ethyl acetate / 24 h / 20 °C

3: 94 percent / oxalyl chloride; DMSO / CH₂Cl₂ / 1 h / -78 °C

With 1H-imidazole; oxalyl dichloride; hydrogen; dimethyl sulfoxide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; acetonitrile; 1: Etherification / 2: Catalytic hydrogenation / 3: Oxidation;