Acetic acid (S)-3-(2-hydroxymethyl-phenyl)-2-[(S)-3-methyl-2-(toluene-4-sulfonylamino)-butyrylamino]-propyl ester

Base Information

Chemical Name:Acetic acid (S)-3-(2-hydroxymethyl-phenyl)-2-[(S)-3-methyl-2-(toluene-4-sulfonylamino)-butyrylamino]-propyl ester
CAS No.:148672-07-5
Molecular Formula:C₂₄H₃₂N₂O₆S
Molecular Weight:476.594
Hs Code.:

Synonyms:Acetic acid (S)-3-(2-hydroxymethyl-phenyl)-2-[(S)-3-methyl-2-(toluene-4-sulfonylamino)-butyrylamino]-propyl ester

Suppliers and Price of Acetic acid (S)-3-(2-hydroxymethyl-phenyl)-2-[(S)-3-methyl-2-(toluene-4-sulfonylamino)-butyrylamino]-propyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Acetic acid (S)-3-(2-hydroxymethyl-phenyl)-2-[(S)-3-methyl-2-(toluene-4-sulfonylamino)-butyrylamino]-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Acetic acid (S)-3-(2-hydroxymethyl-phenyl)-2-[(S)-3-methyl-2-(toluene-4-sulfonylamino)-butyrylamino]-propyl ester

There total 9 articles about Acetic acid (S)-3-(2-hydroxymethyl-phenyl)-2-[(S)-3-methyl-2-(toluene-4-sulfonylamino)-butyrylamino]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 148671-96-9
-O-acetyl-2-formyl-β-<<3-methyl-2-<<(4-methylphenyl)sulfonyl>amino>-1-oxobutyl>amino>benzenepropanol

: 148672-07-5
Acetic acid (S)-3-(2-hydroxymethyl-phenyl)-2-[(S)-3-methyl-2-(toluene-4-sulfonylamino)-butyrylamino]-propyl ester

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; ethanol; at 0 ℃; for 0.5h;
DOI:10.1021/ja00063a015

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 148672-07-5
Acetic acid (S)-3-(2-hydroxymethyl-phenyl)-2-[(S)-3-methyl-2-(toluene-4-sulfonylamino)-butyrylamino]-propyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 72 percent / conc. HCl / 4 h / 90 - 95 °C

2: 76 percent / SOCl₂ / 4.5 h / Heating

3: 40 percent / Et₃N, DCC / CH₂Cl₂ / 24 h / Ambient temperature

4: 79 percent / H₂O, NaOH / methanol / 24 h / Ambient temperature

5: K₂CO₃, KMnO₄ / H₂O / 1.5 h / Ambient temperature

6: 24 percent / BH₃*THF / tetrahydrofuran / 0 - 20 °C

7: MnO₂ / CH₂Cl₂ / 36 h / Ambient temperature

8: pyridine / tetrahydrofuran / 24 h / Ambient temperature

9: 95 percent / NaBH₄ / tetrahydrofuran; ethanol / 0.5 h / 0 °C

With pyridine; hydrogenchloride; manganese(IV) oxide; sodium hydroxide; sodium tetrahydroborate; potassium permanganate; thionyl chloride; borane-THF; water; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1021/ja00063a015

Reference yield:

: 74163-81-8
L-Tic-OH

: 148672-07-5
Acetic acid (S)-3-(2-hydroxymethyl-phenyl)-2-[(S)-3-methyl-2-(toluene-4-sulfonylamino)-butyrylamino]-propyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 76 percent / SOCl₂ / 4.5 h / Heating

2: 40 percent / Et₃N, DCC / CH₂Cl₂ / 24 h / Ambient temperature

3: 79 percent / H₂O, NaOH / methanol / 24 h / Ambient temperature

4: K₂CO₃, KMnO₄ / H₂O / 1.5 h / Ambient temperature

5: 24 percent / BH₃*THF / tetrahydrofuran / 0 - 20 °C

6: MnO₂ / CH₂Cl₂ / 36 h / Ambient temperature

7: pyridine / tetrahydrofuran / 24 h / Ambient temperature

8: 95 percent / NaBH₄ / tetrahydrofuran; ethanol / 0.5 h / 0 °C

With pyridine; manganese(IV) oxide; sodium hydroxide; sodium tetrahydroborate; potassium permanganate; thionyl chloride; borane-THF; water; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1021/ja00063a015