(3R,6S)-2,5-dimethoxy-3-benzyl-3-methyl-6-deuterio-6-<(1R)-2-bromo<1-2H>ethyl>-3,6-dihydropyrazine

Base Information

Chemical Name:(3R,6S)-2,5-dimethoxy-3-benzyl-3-methyl-6-deuterio-6-<(1R)-2-bromo<1-2H>ethyl>-3,6-dihydropyrazine
CAS No.:118111-46-9
Molecular Formula:C₁₆H₂₁BrN₂O₂
Molecular Weight:355.243
Hs Code.:

Synonyms:(3R,6S)-2,5-dimethoxy-3-benzyl-3-methyl-6-deuterio-6-<(1R)-2-bromo<1-2H>ethyl>-3,6-dihydropyrazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,6S)-2,5-dimethoxy-3-benzyl-3-methyl-6-deuterio-6-<(1R)-2-bromo<1-2H>ethyl>-3,6-dihydropyrazine

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Technology Process of (3R,6S)-2,5-dimethoxy-3-benzyl-3-methyl-6-deuterio-6-<(1R)-2-bromo<1-2H>ethyl>-3,6-dihydropyrazine

There total 2 articles about (3R,6S)-2,5-dimethoxy-3-benzyl-3-methyl-6-deuterio-6-<(1R)-2-bromo<1-2H>ethyl>-3,6-dihydropyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.4%

: 420-37-1
trimethoxonium tetrafluoroborate

: 118111-45-8
(3R,6S)-3-benzyl-3-methyl-6-deuterio-6-<(1R)-2-bromo<1-2H>ethyl>piperazine-2,5-dione

: 118111-46-9
(3R,6S)-2,5-dimethoxy-3-benzyl-3-methyl-6-deuterio-6-<(1R)-2-bromo<1-2H>ethyl>-3,6-dihydropyrazine

Guidance literature:: In dichloromethane; at 40 ℃; for 72h;
DOI:10.1021/jo00263a004

Reference yield:

: 118111-42-5
(3R,6S)-3-benzyl-3-methyl-6-deuterio-6-<(1R)-2-hydroxy<1-2H>ethyl>piperazine-2,5-dione

: 118111-46-9
(3R,6S)-2,5-dimethoxy-3-benzyl-3-methyl-6-deuterio-6-<(1R)-2-bromo<1-2H>ethyl>-3,6-dihydropyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: 83.8 percent / Ph₃P, Br₂ / dimethylformamide / a.) 0 deg C, 0.5 h, b.) 10 deg C, 8 h

2: 77.4 percent / CH₂Cl₂ / 72 h / 40 °C

With bromine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00263a004