4-Methoxy-6-phenylpyrimidine

Base Information

• Chemical Name: 4-Methoxy-6-phenylpyrimidine
• CAS No.: 17759-28-3
• Molecular Formula: C₁₁H₁₀N₂O
• Molecular Weight: 186.213
• DSSTox Substance ID: DTXSID001308665
• Nikkaji Number: J2.180.018J
• Mol file: 17759-28-3.mol

Synonyms:4-methoxy-6-phenylpyrimidine;17759-28-3;Pyrimidine, 4-methoxy-6-phenyl-;SCHEMBL9505812;DTXSID001308665;AKOS026679552;F1967-2626

Chemical Property of 4-Methoxy-6-phenylpyrimidine

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 186.079312947
• Heavy Atom Count: 14
• Complexity: 169

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=NC=NC(=C1)C2=CC=CC=C2

Technology Process of 4-Methoxy-6-phenylpyrimidine

There total 1 articles about 4-Methoxy-6-phenylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-chloro-6-methoxy-pyrimidine (26452-81-3) + phenylboronic acid (98-80-6) → 4-methoxy-6-phenyl-pyrimidine (17759-28-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In propan-1-ol; at 90 ℃; for 14h;

DOI:10.1016/j.tetlet.2005.04.043

Reference yield: 94.0%

4-methoxy-6-phenyl-pyrimidine (17759-28-3) → 4-methoxy-6-phenyl-1,2-dihydropyrimidine (104995-39-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;

DOI:10.1021/jo00374a024

upstream raw materials:

4-chloro-6-methoxy-pyrimidine

phenylboronic acid

Downstream raw materials:

4-methoxy-6-phenyl-1,2-dihydropyrimidine