2-((4-amino-3-(3-methyl-1H-indazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-6-fluoro-3-phenyl-4H-chromen-4-one

Base Information

Chemical Name:2-((4-amino-3-(3-methyl-1H-indazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-6-fluoro-3-phenyl-4H-chromen-4-one
CAS No.:1300585-01-6
Molecular Formula:C₂₉H₂₀FN₇O₂
Molecular Weight:517.522
Hs Code.:

Synonyms:2-((4-amino-3-(3-methyl-1H-indazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-6-fluoro-3-phenyl-4H-chromen-4-one

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Chemical Property of 2-((4-amino-3-(3-methyl-1H-indazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-6-fluoro-3-phenyl-4H-chromen-4-one

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Technology Process of 2-((4-amino-3-(3-methyl-1H-indazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-6-fluoro-3-phenyl-4H-chromen-4-one

There total 11 articles about 2-((4-amino-3-(3-methyl-1H-indazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-6-fluoro-3-phenyl-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

: 1300582-45-9
tert-butyl 3-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate

: 1300583-91-8
2-((4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-6-fluoro-3-phenyl-4H-chromen-4-one

: 1300585-01-6
2-((4-amino-3-(3-methyl-1H-indazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-6-fluoro-3-phenyl-4H-chromen-4-one

Guidance literature:: With water; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; N,N-dimethyl-formamide; at 80 ℃; for 12.5h; Inert atmosphere;

Reference yield:

: 57848-46-1
4-bromo-2-fluorobenzaldehyde

: 1300585-01-6
2-((4-amino-3-(3-methyl-1H-indazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-6-fluoro-3-phenyl-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethyl ether / 12 h / 20 °C / Cooling with ice

2.1: dipyridinium dichromate / N,N-dimethyl-formamide / 12 h / 20 °C

3.1: hydrazine hydrate / ethylene glycol / 12 h / 165 °C

4.1: triethylamine / acetonitrile / 12 h / 20 °C

4.2: 20 °C

5.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dichloromethane; 1,4-dioxane / 12.5 h / 80 °C / Inert atmosphere

6.1: water; sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; ethanol / 12.5 h / 80 °C / Inert atmosphere

With dipyridinium dichromate; water; potassium acetate; sodium carbonate; hydrazine hydrate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; diethyl ether; ethanol; dichloromethane; ethylene glycol; N,N-dimethyl-formamide; acetonitrile; 6.1: Suzuki Coupling;

Reference yield:

: 459-60-9
1-fluoro-4-methoxybenzene

: 1300585-01-6
2-((4-amino-3-(3-methyl-1H-indazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-6-fluoro-3-phenyl-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 0 °C

1.2: 12 h / 0 - 20 °C

2.1: sodium acetate / 12 h / Reflux

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 12 h / 80 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 16 h

5.1: water; sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; ethanol / 12.5 h / 80 °C / Inert atmosphere

With N-Bromosuccinimide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); water; sodium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl-formamide; In tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide; 5.1: Suzuki Coupling;