3-tert-butyl-5-{5-[1-(4-chloro-benzenesulfonyl)-1-methyl-ethyl]-1H-imidazol-2-yl}-1-methyl-1H-pyrazole

Base Information

Chemical Name:3-tert-butyl-5-{5-[1-(4-chloro-benzenesulfonyl)-1-methyl-ethyl]-1H-imidazol-2-yl}-1-methyl-1H-pyrazole
CAS No.:1196103-46-4
Molecular Formula:C₂₀H₂₅ClN₄O₂S
Molecular Weight:420.963
Hs Code.:

Synonyms:3-tert-butyl-5-{5-[1-(4-chloro-benzenesulfonyl)-1-methyl-ethyl]-1H-imidazol-2-yl}-1-methyl-1H-pyrazole

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Chemical Property of 3-tert-butyl-5-{5-[1-(4-chloro-benzenesulfonyl)-1-methyl-ethyl]-1H-imidazol-2-yl}-1-methyl-1H-pyrazole

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Technology Process of 3-tert-butyl-5-{5-[1-(4-chloro-benzenesulfonyl)-1-methyl-ethyl]-1H-imidazol-2-yl}-1-methyl-1H-pyrazole

There total 7 articles about 3-tert-butyl-5-{5-[1-(4-chloro-benzenesulfonyl)-1-methyl-ethyl]-1H-imidazol-2-yl}-1-methyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

: 1196103-99-7
5-tert-butyl-2-methyl-2H-pyrazole-3-carboxamidine

: 1196104-25-2
1-bromo-3-(4-chloro-benzenesulfonyl)-3-methyl-butan-2-one

: 1196103-46-4
3-tert-butyl-5-{5-[1-(4-chloro-benzenesulfonyl)-1-methyl-ethyl]-1H-imidazol-2-yl}-1-methyl-1H-pyrazole

Guidance literature:: In isopropyl alcohol; at 70 ℃; for 3h;

Reference yield:

: 28361-38-8
2-(4-chloro-benzenesulfonyl)-2-methyl-propionic acid

: 1196103-46-4
3-tert-butyl-5-{5-[1-(4-chloro-benzenesulfonyl)-1-methyl-ethyl]-1H-imidazol-2-yl}-1-methyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2: dichloromethane / 1 h / 20 °C

3: methyllithium / diethyl ether; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4: isopropyl alcohol / 3 h / 70 °C

With oxalyl dichloride; methyllithium; N,N-dimethyl-formamide; In tetrahydrofuran; diethyl ether; dichloromethane; isopropyl alcohol;

Reference yield:

: 160842-62-6
3-tert-Butyl-1-methyl-1H-pyrazole-5-carbonyl chloride

: 1196103-46-4
3-tert-butyl-5-{5-[1-(4-chloro-benzenesulfonyl)-1-methyl-ethyl]-1H-imidazol-2-yl}-1-methyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium hydroxide / dichloromethane / 2 h / 0 - 20 °C

2.1: trichlorophosphate / 24 h / 60 °C

3.1: sodium hydride; methanol / mineral oil / 2 h / 40 °C / Inert atmosphere

3.2: 16 h / 70 °C

4.1: isopropyl alcohol / 3 h / 70 °C

With methanol; ammonium hydroxide; sodium hydride; trichlorophosphate; In dichloromethane; isopropyl alcohol; mineral oil;