Technology Process of (2S)-4-cyclohexyl-4-oxo-3-methyl-3-phenylbutanal
There total 12 articles about (2S)-4-cyclohexyl-4-oxo-3-methyl-3-phenylbutanal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
at -60 ℃;
for 2h;
DOI:10.1021/jo052203h
- Guidance literature:
-
C17H26O2;
With
oxalyl dichloride; dimethyl sulfoxide;
In
dichloromethane;
at -70 ℃;
for 1.5h;
With
triethylamine;
In
dichloromethane;
at -70 - -30 ℃;
for 2h;
DOI:10.1016/j.tet.2018.02.045
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 93 percent / N-chlorosuccinimide; dimethyl sulfide / CH2Cl2 / 4 h / -40 - 20 °C
2.1: 84 percent / diisopropylethylamine; CuCl; trichlorosilane / diethyl ether / 18 h / 20 °C
3.1: diisopropylethylamine; chiral phosphoramide / CH2Cl2 / 16 h / -78 °C
4.1: 9-borabicyclo[3.3.1]nonane / tetrahydrofuran / 3 h / Heating
4.2: sodium perborate; sodium hydroxide / tetrahydrofuran; H2O / 4 h / 50 °C
5.1: hydrogen / Rh/Al2O3 / methanol; acetic acid / 3 h / 2585.74 Torr
5.2: 74 percent / hydrogen / Pt/C / methanol; acetic acid / 12 h / 15514.4 Torr
6.1: 87 percent / oxalyl chloride; dimethyl sulfoxide; triethylamine / CH2Cl2 / 2 h / -60 °C
With
N-chloro-succinimide; oxalyl dichloride; dimethylsulfide; trichlorosilane; hydrogen; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; 9-bora-bicyclo[3.3.1]nonane; copper(l) chloride;
Rh/Al2O3;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetic acid;
6.1: Swern oxidation;
DOI:10.1021/jo052203h
