tert-butyl 2-{1-[chloro(p-tolylsulfinyl)methyl]-1-methylethyl}hexanoate

Base Information

• Chemical Name: tert-butyl 2-{1-[chloro(p-tolylsulfinyl)methyl]-1-methylethyl}hexanoate
• CAS No.: 867150-95-6
• Molecular Formula: C₂₁H₃₃ClO₃S
• Molecular Weight: 401.01

Synonyms:tert-butyl 2-{1-[chloro(p-tolylsulfinyl)methyl]-1-methylethyl}hexanoate

Chemical Property of tert-butyl 2-{1-[chloro(p-tolylsulfinyl)methyl]-1-methylethyl}hexanoate

Chemical Property:

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Technology Process of tert-butyl 2-{1-[chloro(p-tolylsulfinyl)methyl]-1-methylethyl}hexanoate

There total 2 articles about tert-butyl 2-{1-[chloro(p-tolylsulfinyl)methyl]-1-methylethyl}hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-((R)-1-Chloro-2-methyl-prop-1-ene-1-sulfinyl)-4-methyl-benzene (867150-83-2) + tert-butyl hexanoate (2492-18-4) → tert-butyl 2-{1-[chloro(p-tolylsulfinyl)methyl]-1-methylethyl}hexanoate (867150-95-6)

Guidance literature:

tert-butyl hexanoate; With lithium diisopropyl amide; In tetrahydrofuran; at -75 ℃;

1-((R)-1-Chloro-2-methyl-prop-1-ene-1-sulfinyl)-4-methyl-benzene; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2005.06.172

Reference yield:

(R)-chloromethyl p-tolyl sulfoxide (31350-91-1) → tert-butyl 2-{1-[chloro(p-tolylsulfinyl)methyl]-1-methylethyl}hexanoate (867150-95-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran / -75 °C

1.2: 99 percent / tetrahydrofuran / -75 °C

With lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1016/j.tetasy.2007.07.033

Reference yield: 93.0%

tert-butyl 2-{1-[chloro(p-tolylsulfinyl)methyl]-1-methylethyl}hexanoate (867150-95-6) → (R)-2-[1,1-Dimethyl-2-((S)-toluene-4-sulfinyl)-ethyl]-hexanoic acid tert-butyl ester (867151-02-8)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; Heating;

DOI:10.1016/j.tetlet.2005.06.172

upstream raw materials:

1-((R)-1-Chloro-2-methyl-prop-1-ene-1-sulfinyl)-4-methyl-benzene

tert-butyl hexanoate

(R)-chloromethyl p-tolyl sulfoxide

Downstream raw materials:

(R)-2-[1,1-Dimethyl-2-((S)-toluene-4-sulfinyl)-ethyl]-hexanoic acid tert-butyl ester

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