4-(2-fluoropyridin-4-yl)-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid potassium salt

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Chemical Name:4-(2-fluoropyridin-4-yl)-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid potassium salt
CAS No.:1418287-60-1
Molecular Formula:C₂₂H₁₄F₄N₃O₄*K
Molecular Weight:499.463
Hs Code.:

Synonyms:4-(2-fluoropyridin-4-yl)-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid potassium salt

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Chemical Property of 4-(2-fluoropyridin-4-yl)-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid potassium salt

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Technology Process of 4-(2-fluoropyridin-4-yl)-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid potassium salt

There total 7 articles about 4-(2-fluoropyridin-4-yl)-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid potassium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₁₇F₄N₃O₄

: 1418287-60-1
4-(2-fluoropyridin-4-yl)-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid potassium salt

Guidance literature:: With potassium trimethylsilonate; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: 688357-19-9
4-chloro-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid methyl ester

: 1418287-60-1
4-(2-fluoropyridin-4-yl)-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid potassium salt

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 4 h / 60 °C

2: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 100 °C / Inert atmosphere

3: potassium trimethylsilonate / tetrahydrofuran / 3 h / 20 °C

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium trimethylsilonate; sodium hydride; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1418287-59-8
methyl 4-chloro-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

: 1418287-60-1
4-(2-fluoropyridin-4-yl)-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid potassium salt

Guidance literature:: Multi-step reaction with 2 steps

1: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 100 °C / Inert atmosphere

2: potassium trimethylsilonate / tetrahydrofuran / 3 h / 20 °C

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium trimethylsilonate; In tetrahydrofuran; 1,4-dioxane;