5-hydroxy-3-oxo-7-t.butyldiphenylsilyloxy-heptanoic acid α-methylbenzyl ester

Base Information

• Chemical Name: 5-hydroxy-3-oxo-7-t.butyldiphenylsilyloxy-heptanoic acid α-methylbenzyl ester
• CAS No.: 155504-67-9
• Molecular Formula: C₃₁H₃₈O₅Si
• Molecular Weight: 518.725
• Mol file: 155504-67-9.mol

Synonyms:5-hydroxy-3-oxo-7-t.butyldiphenylsilyloxy-heptanoic acid α-methylbenzyl ester

Chemical Property of 5-hydroxy-3-oxo-7-t.butyldiphenylsilyloxy-heptanoic acid α-methylbenzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-hydroxy-3-oxo-7-t.butyldiphenylsilyloxy-heptanoic acid α-methylbenzyl ester

There total 2 articles about 5-hydroxy-3-oxo-7-t.butyldiphenylsilyloxy-heptanoic acid α-methylbenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → 5-hydroxy-3-oxo-7-t.butyldiphenylsilyloxy-heptanoic acid α-methylbenzyl ester (155504-67-9)

Guidance literature:

Multi-step reaction with 3 steps

1: imidazole / dimethylformamide / 16 h / Ambient temperature

2: 80 percent / iBu₂AlH / CH₂Cl₂; toluene / 3 h / -70 °C

3: 1.) TiCl₄ / 1.) CH₂Cl₂, -78 deg C, 5 min; 2.) -10/-20 deg C,

With 1H-imidazole; titanium tetrachloride; diisobutylaluminium hydride; In dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0040-4020(01)85067-5

Reference yield:

3-tert.butyldiphenylsilyloxy-propionitrile (130442-55-6) → 5-hydroxy-3-oxo-7-t.butyldiphenylsilyloxy-heptanoic acid α-methylbenzyl ester (155504-67-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / iBu₂AlH / CH₂Cl₂; toluene / 3 h / -70 °C

2: 1.) TiCl₄ / 1.) CH₂Cl₂, -78 deg C, 5 min; 2.) -10/-20 deg C,

With titanium tetrachloride; diisobutylaluminium hydride; In dichloromethane; toluene;

DOI:10.1016/S0040-4020(01)85067-5

Reference yield: 72.0%

5-hydroxy-3-oxo-7-t.butyldiphenylsilyloxy-heptanoic acid α-methylbenzyl ester (155504-67-9) → (2',4'-dihydroxy-tetrahydro-pyran-2'-yl)-acetic acid α-methylbenzyl ester

Guidance literature:

With pyridine; hydrogen fluoride; In tetrahydrofuran; for 1h;

DOI:10.1016/S0040-4020(01)85067-5

upstream raw materials:

tert-butylchlorodiphenylsilane

3-tert.butyldiphenylsilyloxy-propionitrile