{(2S,3S)-1-Benzyl-2-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-3-yl}-carbamic acid benzyl ester

Base Information

Chemical Name:{(2S,3S)-1-Benzyl-2-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-3-yl}-carbamic acid benzyl ester
CAS No.:208347-82-4
Molecular Formula:C₂₆H₃₆N₂O₄Si
Molecular Weight:468.668
Hs Code.:

Synonyms:{(2S,3S)-1-Benzyl-2-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-3-yl}-carbamic acid benzyl ester

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Chemical Property of {(2S,3S)-1-Benzyl-2-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-3-yl}-carbamic acid benzyl ester

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Technology Process of {(2S,3S)-1-Benzyl-2-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-3-yl}-carbamic acid benzyl ester

There total 8 articles about {(2S,3S)-1-Benzyl-2-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-3-yl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 208347-76-6
C₃₄H₄₂N₂O₆Si

: 208347-82-4
{(2S,3S)-1-Benzyl-2-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-3-yl}-carbamic acid benzyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; under 760 Torr; Yield given; Ambient temperature;
DOI:10.1055/s-1998-1726

Reference yield:

: 132629-26-6
dibenzyl iminodicarboxylate potassium salt

: 208347-82-4
{(2S,3S)-1-Benzyl-2-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-3-yl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: NaH / tetrahydrofuran / 2 h / Heating

2: TiCl₄ / CH₂Cl₂ / 0.02 h / 0 °C

3: (COCl)2 / CH₂Cl₂ / 3 h / Ambient temperature

4: 60 percent / Et₃N / CH₂Cl₂ / -40 °C

5: H₂ / 10percent Pd/C / tetrahydrofuran / 760 Torr / Ambient temperature

With oxalyl dichloride; hydrogen; titanium tetrachloride; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-1998-1726

Reference yield:

: 87727-28-4
(S)-2-tert-butyl-dimethyl-silanyloxy propanal

: 208347-82-4
{(2S,3S)-1-Benzyl-2-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-3-yl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: MgSO₄ / CH₂Cl₂ / Ambient temperature

2: 60 percent / Et₃N / CH₂Cl₂ / -40 °C

3: H₂ / 10percent Pd/C / tetrahydrofuran / 760 Torr / Ambient temperature

With hydrogen; magnesium sulfate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-1998-1726