tert-butyl 4-(2-amino-4-bromophenyl)piperazine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(2-amino-4-bromophenyl)piperazine-1-carboxylate
• CAS No.: 474329-58-3
• Molecular Formula: C₁₅H₂₂BrN₃O₂
• Molecular Weight: 356.263
• Mol file: 474329-58-3.mol

Synonyms:4-(2-amino-4-bromo-phenyl)-1-tert-butoxycarbonyl-piperazine

Chemical Property of tert-butyl 4-(2-amino-4-bromophenyl)piperazine-1-carboxylate

Chemical Property:

Purity/Quality:

tert-butyl4-(2-amino-4-bromophenyl)piperazine-1-carboxylate 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(2-amino-4-bromophenyl)piperazine-1-carboxylate

There total 4 articles about tert-butyl 4-(2-amino-4-bromophenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-(4-bromo-2-nitro-phenyl)-1-tert-butoxycarbonyl-piperazine (474329-57-2) → 4-(2-amino-4-bromo-phenyl)-1-tert-butoxycarbonyl-piperazine (474329-58-3)

Guidance literature:

With sodium dithionate; sodium carbonate; In methanol; water; at 70 ℃;

DOI:10.1016/j.bmc.2013.01.064

Reference yield: 96.0%

4-(4-bromo-2-nitro-phenyl)-1-tert-butoxycarbonyl-piperazine (474329-57-2) + NiCl2 hexahydrate → 4-(2-amino-4-bromo-phenyl)-1-tert-butoxycarbonyl-piperazine (474329-58-3)

Guidance literature:

With sodium tetrahydroborate; In methanol; dichloromethane;

Reference yield:

1,4-dibromo-2-nitrobenzene (3460-18-2) → 4-(2-amino-4-bromo-phenyl)-1-tert-butoxycarbonyl-piperazine (474329-58-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / triethylamine / propan-2-ol / 24 h / 70 °C

2: 63 percent / Zn; aq. KH₂PO₄ / tetrahydrofuran / 24 h / 80 °C

With potassium dihydrogenphosphate; triethylamine; zinc; In tetrahydrofuran; isopropyl alcohol;

DOI:10.1021/jm0602864

upstream raw materials:

4-(4-bromo-2-nitro-phenyl)-1-tert-butoxycarbonyl-piperazine

1,4-dibromo-2-nitrobenzene

1-t-Butoxycarbonylpiperazine

Downstream raw materials:

4-{4-bromo-2-[(quinoline-2-carbonyl)-amino]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester

4-{4-bromo-2-[(4-oxo-4H-chromene-2-carbonyl)-amino]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester

4-{4-bromo-2-[(2-oxo-2H-chromene-3-carbonyl)-amino]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester

4-{4-bromo-2-[(8-methoxy-2-oxo-2H-chromene-3-carbonyl)-amino]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester