2-((5-amino-7-bromo-3-chloro-5H-chromeno[2,3-c]pyridin-5-yl)methoxy)-2-cyclohexylacetonitrile

Base Information

Chemical Name:2-((5-amino-7-bromo-3-chloro-5H-chromeno[2,3-c]pyridin-5-yl)methoxy)-2-cyclohexylacetonitrile
CAS No.:1335219-19-6
Molecular Formula:C₂₁H₂₁BrClN₃O₂
Molecular Weight:462.774
Hs Code.:

Synonyms:2-((5-amino-7-bromo-3-chloro-5H-chromeno[2,3-c]pyridin-5-yl)methoxy)-2-cyclohexylacetonitrile

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Chemical Property of 2-((5-amino-7-bromo-3-chloro-5H-chromeno[2,3-c]pyridin-5-yl)methoxy)-2-cyclohexylacetonitrile

Chemical Property:

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Technology Process of 2-((5-amino-7-bromo-3-chloro-5H-chromeno[2,3-c]pyridin-5-yl)methoxy)-2-cyclohexylacetonitrile

There total 11 articles about 2-((5-amino-7-bromo-3-chloro-5H-chromeno[2,3-c]pyridin-5-yl)methoxy)-2-cyclohexylacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1335219-18-5
7-bromo-3-chloro-5-((1-cyclohexyl-2-nitroethoxy)methyl)-5H-chromeno[2,3-c]pyridin-5-amine

: 1335219-19-6
2-((5-amino-7-bromo-3-chloro-5H-chromeno[2,3-c]pyridin-5-yl)methoxy)-2-cyclohexylacetonitrile

Guidance literature:: With phosphorous triiodide; triethylamine; In dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

: 2043-61-0
cyclohexanecarbaldehyde

: 1335219-19-6
2-((5-amino-7-bromo-3-chloro-5H-chromeno[2,3-c]pyridin-5-yl)methoxy)-2-cyclohexylacetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / ethanol; water / 0.17 h

2.1: methanesulfonyl chloride; triethylamine; hydroquinone / dichloromethane; water / 0.33 h / 0 °C

3.1: potassium tert-butylate / tetrahydrofuran / 0.75 h / -78 °C

3.2: 0.33 h / -78 °C

4.1: phosphorous triiodide; triethylamine / dichloromethane / 1.5 h / 20 °C

With potassium tert-butylate; phosphorous triiodide; methanesulfonyl chloride; triethylamine; hydroquinone; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

: 41288-96-4
6-chloropyridine-3-ol

: 1335219-19-6
2-((5-amino-7-bromo-3-chloro-5H-chromeno[2,3-c]pyridin-5-yl)methoxy)-2-cyclohexylacetonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / 0.33 h / Inert atmosphere; Industry scale

1.2: 2 h / 105 °C

1.3: pH 2 - 3

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Industry scale

3.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.5 h / -78 - -70 °C

3.2: 10 °C

4.1: trimethylsulphonium iodide; potassium tert-butylate / dimethyl sulfoxide / 2 h / 20 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / 0 - 20 °C

6.1: potassium tert-butylate / tetrahydrofuran / 0.75 h / -78 °C

6.2: 0.33 h / -78 °C

7.1: phosphorous triiodide; triethylamine / dichloromethane / 1.5 h / 20 °C

With lithium aluminium tetrahydride; trimethylsulphonium iodide; potassium tert-butylate; phosphorous triiodide; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane; ethylbenzene; dimethyl sulfoxide;