(7R,8R,9S,13S,14S,17S)-7-(5-(benzyloxy)pentyl)-3,17-bis(methoxymethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene

Base Information

Chemical Name:(7R,8R,9S,13S,14S,17S)-7-(5-(benzyloxy)pentyl)-3,17-bis(methoxymethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene
CAS No.:1448189-20-5
Molecular Formula:C₃₄H₄₈O₅
Molecular Weight:536.752
Hs Code.:

Synonyms:(7R,8R,9S,13S,14S,17S)-7-(5-(benzyloxy)pentyl)-3,17-bis(methoxymethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene

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Chemical Property of (7R,8R,9S,13S,14S,17S)-7-(5-(benzyloxy)pentyl)-3,17-bis(methoxymethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene

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Technology Process of (7R,8R,9S,13S,14S,17S)-7-(5-(benzyloxy)pentyl)-3,17-bis(methoxymethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene

There total 5 articles about (7R,8R,9S,13S,14S,17S)-7-(5-(benzyloxy)pentyl)-3,17-bis(methoxymethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1448189-19-2
(7R,8R,9S,13S,14S,17S)-7-(5-(benzyloxy)pentyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol

: 107-30-2
chloromethyl methyl ether

: 1448189-20-5
(7R,8R,9S,13S,14S,17S)-7-(5-(benzyloxy)pentyl)-3,17-bis(methoxymethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 70 ℃; for 48h; Inert atmosphere; Sealed tube;

Reference yield:

: 84885-76-7
(((5-iodopentyl)oxy)methyl)benzene

: 1448189-20-5
(7R,8R,9S,13S,14S,17S)-7-(5-(benzyloxy)pentyl)-3,17-bis(methoxymethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.75 h / 0 °C

1.2: 1.03 h / -78 - 0 °C

2.1: hydrogenchloride / tetrahydrofuran; water / 16 h / 20 °C

3.1: triethylsilane; trifluoroacetic acid / 16 h / 20 °C / Inert atmosphere

3.2: 3 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 48 h / 70 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; triethylsilane; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; water;

Reference yield:

: 1448189-18-1
(7S,8R,9S,13S,14S,17S)-7-(5-(benzyloxy)pentyl)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-6-one

: 1448189-20-5
(7R,8R,9S,13S,14S,17S)-7-(5-(benzyloxy)pentyl)-3,17-bis(methoxymethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylsilane; trifluoroacetic acid / 16 h / 20 °C / Inert atmosphere

1.2: 3 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 48 h / 70 °C / Inert atmosphere; Sealed tube

With triethylsilane; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran;