ethyl (4RS,5R,6R)-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-(4-methoxybenzoxy)-2-methylene-7-octenoate

Base Information

Chemical Name:ethyl (4RS,5R,6R)-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-(4-methoxybenzoxy)-2-methylene-7-octenoate
CAS No.:1373390-61-4
Molecular Formula:C₂₄H₃₅NO₇
Molecular Weight:449.544
Hs Code.:

Synonyms:ethyl (4RS,5R,6R)-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-(4-methoxybenzoxy)-2-methylene-7-octenoate

Suppliers and Price of ethyl (4RS,5R,6R)-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-(4-methoxybenzoxy)-2-methylene-7-octenoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl (4RS,5R,6R)-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-(4-methoxybenzoxy)-2-methylene-7-octenoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl (4RS,5R,6R)-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-(4-methoxybenzoxy)-2-methylene-7-octenoate

There total 4 articles about ethyl (4RS,5R,6R)-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-(4-methoxybenzoxy)-2-methylene-7-octenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: (2S,3R)-2-(tert-butoxycarbonyl)amino-3-(4-methoxybenzoxy)-4-pentenal

: 17435-72-2
ethyl 2-bromomethyl-2-propenoate

: 1373390-61-4
ethyl (4RS,5R,6R)-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-(4-methoxybenzoxy)-2-methylene-7-octenoate

Guidance literature:: With indium; In ethanol; water; at 25 ℃; for 6h;
DOI:10.1002/jccs.201100637

Reference yield:

: (2R,3R)-2-(tert-butoxycarbonyl)amino-3-(4-methoxybenzoxy)-4-penten-1-ol

: 1373390-61-4
ethyl (4RS,5R,6R)-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-(4-methoxybenzoxy)-2-methylene-7-octenoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.25 h / -78 °C

1.2: 0.58 h / 0 °C

2.1: indium / ethanol; water / 6 h / 25 °C

With indium; oxalyl dichloride; dimethyl sulfoxide; In ethanol; dichloromethane; water; 1.1: Swern oxidation / 1.2: Swern oxidation / 2.1: Reformatsky reaction;
DOI:10.1002/jccs.201100637

Reference yield:

: 108149-60-6,95715-86-9
methyl [(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]carboxylate

: 1373390-61-4
ethyl (4RS,5R,6R)-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-(4-methoxybenzoxy)-2-methylene-7-octenoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.67 h / 25 °C

2.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 2 h / -78 °C

3.1: methyllithium / diethyl ether / 15 h / 0 °C

3.2: 1 h / 20 °C

3.3: 2.33 h / -78 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 25 °C

5.1: toluene-4-sulfonic acid / methanol / 3 h / 25 °C

6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.25 h / -78 °C

6.2: 0.58 h / 0 °C

7.1: indium / ethanol; water / 6 h / 25 °C

With indium; lithium aluminium tetrahydride; oxalyl dichloride; methyllithium; sodium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 2.1: Swern oxidation / 6.1: Swern oxidation / 6.2: Swern oxidation / 7.1: Reformatsky reaction;
DOI:10.1002/jccs.201100637